ArticleScientific reports2020
Genome mining of biosynthetic and chemotherapeutic gene clusters in Streptomyces bacteria.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers.
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Who cites it
144 citing papers in PubMed, 226 citations in OpenAlex.
- Evolutionary strategies of late-stage diversification in bacterial biosynthetic gene clusters.Essays in biochemistry · 2026Review
- Considering internal conflict in the face of natural product biosynthesis and biosynthetic gene cluster evolution.Essays in biochemistry · 2026Review
- Expanding perspectives on specialized metabolism in Streptomyces bacteria.Essays in biochemistry · 2026Review
- A Promising Strain for Wheat Growth Promotion and Antifungal Activity Against Fungal Phytopathogens:Microorganisms · 2026Article
- Environmental filtering shapes biosynthetic potential and resistome of antarctic microbiomes.World journal of microbiology & biotechnology · 2026Article
- Unlocking the Bioactive Potential of Streptomyces: A Multidisciplinary Approach to Strain Improvement.MicrobiologyOpen · 2026Review
- Comparative genome analysis and secondary biosynthetic potential of the Streptomyces microflavus strains isolated from high altitude.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Nocardia fodinahabitans sp. nov. isolated from underground hard coal mine waters shows biotechnological potential for degradation of aromatic hydrocarbons.Molecular genetics and genomics : MGG · 2026Article
- Activation of a gene cluster in Streptomyces lavendulae subsp. lavendulae CCM 3239 induced strevertene production.Applied microbiology and biotechnology · 2026Article
- Endostemonine I as a Multi-Target Inhibitor of Kaposi's Sarcoma-Associated Herpesvirus Oncogenic Pathways: An Integrative Computational Study.Medical sciences (Basel, Switzerland) · 2026Article
- The Computational Revolution in Natural Product Research: A Data-Driven Roadmap for Next-Generation Drug Development.Biology · 2026Review
- De-novo assembly of 82 bacterial genomes using Nanopore sequencing and prediction of biosynthetic capacity.Scientific data · 2026Article
- Identification of NovelMicroorganisms · 2026Article
- Genomic insights and biosynthetic gene cluster analysis ofMicrobiology spectrum · 2026Article
- Genomic, biological, and chemical studies of Streptomyces sp. LaBMicrA B280 isolated from the rhizosphere of Inga edulis Martius in the Amazon.Antonie van Leeuwenhoek · 2026Article
- Characterization of Streptomyces tatrensis sp. nov., isolated from a cave located in Tatra mountains in Poland.Archives of microbiology · 2026Article
- The undiscovered natural product potential of Actinomycetes.The Journal of antibiotics · 2026Article
- Genomic landscape of biosynthetic gene clusters in Iranian extremophiles reveals prolific metabolite potential, prophage associations, and integrated defensive-metabolic islands.BMC microbiology · 2026Article
- Mechanistic insights and biotechnological applications of Streptomyces secondary metabolites in plant abiotic stress mitigation.World journal of microbiology & biotechnology · 2026Review
- Eco-evolutionary dynamics sustain a potent yet rare antibiotic gene cluster in Streptomyces.The ISME journal · 2026Article
84 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Streptomyces bacteria are known for their prolific production of secondary metabolites, many of which have been widely used in human medicine, agriculture and animal health. To guide the effective prioritization of specific biosynthetic gene clusters (BGCs) for drug development and targeting the most prolific producer strains, knowledge about phylogenetic relationships of Streptomyces species, genome-wide diversity and distribution patterns of BGCs is critical. We used genomic and phylogenetic methods to elucidate the diversity of major classes of BGCs in 1,110 publicly available Streptomyces genomes. Genome mining of Streptomyces reveals high diversity of BGCs and variable distribution patterns in the Streptomyces phylogeny, even among very closely related strains. The most common BGCs are non-ribosomal peptide synthetases, type 1 polyketide synthases, terpenes, and lantipeptides. We also found that numerous Streptomyces species harbor BGCs known to encode antitumor compounds. We observed that strains that are considered the same species can vary tremendously in the BGCs they carry, suggesting that strain-level genome sequencing can uncover high levels of BGC diversity and potentially useful derivatives of any one compound. These findings suggest that a strain-level strategy for exploring secondary metabolites for clinical use provides an alternative or complementary approach to discovering novel pharmaceutical compounds from microbes.
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