Evidence map›Paper›PMID 32029838›Full record

ArticleScientific reports2020

Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia.

Toni Grönroos, Artturi Mäkinen, Saara Laukkanen, Juha Mehtonen, Atte Nikkilä, Laura Oksa, Samuli Rounioja, Yanara Marincevic-Zuniga, Jessica Nordlund, Virva Pohjolainen and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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  6. Cancers · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Toni Grönroos *Tampere Center for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. toni.gronroos@tuni.fi.
Artturi Mäkinen *Tampere Center for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Saara LaukkanenTampere Center for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Juha MehtonenInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0003-0554-4667
Atte NikkiläTampere Center for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Laura OksaTampere Center for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Samuli RouniojaFimlab Laboratories, Department of Hematology, Tampere University Hospital, Tampere, Finland.
Yanara Marincevic-ZunigaDepartment of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Jessica NordlundDepartment of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Virva PohjolainenFimlab Laboratories, Department of Pathology, Tampere University Hospital, Tampere, Finland.
Timo PaavonenFimlab Laboratories, Department of Pathology, Tampere University Hospital, Tampere, Finland.
Merja HeinäniemiInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
Olli LohiTampere Center for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Tampere University · FITampere University Hospital · FIUniversity of Eastern Finland · FIUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting altered and subtype-specific expression patterns in B-ALL and report here that SOX11, a developmental and neuronal transcription factor, is aberrantly expressed in the ETV6-RUNX1 and TCF3-PBX1 subtypes of acute B-cell leukemias. We show that a high expression of SOX11 leads to alterations of gene expression that are typically associated with cell adhesion, migration, and differentiation. A high expression is associated with DNA hypomethylation at the SOX11 locus and a favorable outcome. The results indicate that SOX11 expression marks a group of patients with good outcomes and thereby prompts further study of its use as a biomarker.

Indexed as

Gene Expression Regulation, LeukemicAdolescentBiomarkers, TumorBiopsyBone MarrowCell AdhesionCell DifferentiationCell Line, TumorCell MovementChildChild, PreschoolCore Binding Factor Alpha 2 SubunitDisease-Free SurvivalDNA MethylationETS Translocation Variant 6 ProteinFemaleBiomarkers, TumorCore Binding Factor Alpha 2 SubunitETS Translocation Variant 6 ProteinOncogene Proteins, FusionSOX11 protein, humanSOXC Transcription FactorsTCF3-PBX1 fusion protein, humanTEL-AML1 fusion protein

Identifiers

PMID32029838
PMCPMC7005266
OpenAlexW3004630875

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.