Observational studyScientific reports2020
Self-reported sleep disturbance in Crohn's disease is not confirmed by objective sleep measures.
Observational study in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Associations between early-life mental health and abnormal sleep duration in midlife: findings from a prospective cohort study in Great Britain.European journal of epidemiology · 2026Article
- Long-term risk of bowel resection and mortality associated with sleep behaviours and sleep pattern in patients with inflammatory bowel disease: a large-scale prospective cohort study.Family medicine and community health · 2026Article
- Evaluation of inflammatory bowel disease-related sleep disorders based on an interpretable machine learning approach: a multicenter study in China.Therapeutic advances in gastroenterology · 2025Article
- Poor sleep quality is common and independently associated with disease activity and poor quality of life in inflammatory bowel disease: a long-term follow-up study.Therapeutic advances in gastroenterology · 2025Article
- Subjective and objective sleep quality assessment in adolescent patients with inflammatory bowel disease.Sleep medicine: X · 2024Article
- Prevalence and risk factors of sleep disorders in inflammatory bowel disease: a cross-sectional study.International journal of colorectal disease · 2024Article
- Sleep quality is associated with reduced quality of life in inflammatory bowel disease through its interaction with pain.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Latent profiles of fatigue in inflammatory bowel disease.BMC gastroenterology · 2024Article
- Unraveling the fatigue puzzle: insights into the pathogenesis and management of IBD-related fatigue including the role of the gut-brain axis.Frontiers in medicine · 2024Review
- Depression influences fatigue in inflammatory bowel disease amongst other factors: a structural modelling approach.Therapeutic advances in gastroenterology · 2024Article
- Evidence linking gut-brain axis and Crohn's disease, focusing on neurotrophic dysfunctions and radiological imaging analysis - a systematic review.American journal of translational research · 2024Article
- Washed Microbiota Transplantation Improves the Sleep Quality in Patients with Inflammatory Bowel Disease.Nature and science of sleep · 2024Article
- Insomnia is common in inflammatory bowel disease (IBD) and is associated with mental health conditions as well as IBD activity.Intestinal research · 2024Article
- Relationship between disease activity index and sleep disorders in children with inflammatory bowel diseases.European journal of pediatrics · 2023Article
- Simple Novel Screening Tool for Obstructive Sleep Apnea in Inflammatory Bowel Disease.Crohn's & colitis 360 · 2023Article
- Examining the influence of inflammatory bowel disease medications on sleep quality.JGH open : an open access journal of gastroenterology and hepatology · 2023Article
- Systematic review and meta-analysis of sleep quality in inactive inflammatory bowel disease.JGH open : an open access journal of gastroenterology and hepatology · 2022Review
- Sleep disorders related to nutrition and digestive diseases: a neglected clinical condition.International journal of medical sciences · 2021Review
- Inflammatory Bowel Disease and Sleep Disturbance: As Usual, Quality Matters.Digestive diseases and sciences · 2021Article
- Determinants of Sleep Quality in Inflammatory Bowel Diseases.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Sleep disturbance and fatigue are commonly reported among patients with Crohn's disease (CD). In this prospective study, we aimed to define sleep quality in CD patients at various disease activity states and compare to healthy controls using objective and subjective measures. A prospective observational cohort study of CD patients seen at a tertiary academic inflammatory bowel diseases (IBD) clinic was compared to healthy volunteers. CD activity was assessed using the Harvey-Bradshaw Index (HBI). Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) and objectively over 1-week using actigraphy (motion-based) and morning urinary melatonin metabolite. 121 subjects (CD patients N = 61; controls N = 60) completed the study. 34 had active CD (HBI > 4). Sleep disturbance was more frequently reported by CD subjects than controls (PSQI: 57% vs. 35%, p = 0.02) and in patients with active CD versus in remission state (PSQI 75.8% vs. 33.3%, p < 0.01; ESS: 45.5% vs. 19%, p = 0.03). Sleep parameters as measured by actigraphy and urine melatonin metabolite did not vary by group. Crohn's patients report significantly more disturbed sleep than controls. However, poor sleep was not confirmed by objective measures of sleep quality. Excessive daytime sleepiness in CD patients may be driven by factors beyond objectively measured poor sleep.
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