ArticleScientific reports2020
Ultrasonically and Iontophoretically Enhanced Drug-Delivery System Based on Dissolving Microneedle Patches.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 97 citations in OpenAlex.
- Numerical simulation of PDRN iontophoresis: comparison with passive diffusion and key parameter analysis.Drug delivery · 2026Article
- Driving Drugs Deeper: Force-Driven Microneedle Systems for Active Therapy and Their Road Towards Clinical Implementation.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Microneedle-mediated intelligent combination delivery for hair regeneration: A comprehensive review of technologies, mechanistic evidence, and translational prospects.Materials today. Bio · 2026Review
- Bioelectronic Considerations in Biomedical Microneedles.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Polymer Microneedles for Localized Drug Delivery in Musculoskeletal Tissue Regeneration.Journal of functional biomaterials · 2026Review
- Membrane-camouflaged nanoparticle alleviates intervertebral disc degeneration via oxidative stress suppression and autophagy activation.Materials today. Bio · 2026Article
- Ultrasound Patches Toward Intelligent Theranostics: From Flexible Materials to Closed-Loop Biomedical Systems.Bioengineering (Basel, Switzerland) · 2026Review
- Recent advances in electric-stimulus assisted microneedle patches for skin disease treatment.Journal of nanobiotechnology · 2025Review
- Recent advances in iontophoresis-assisted microneedle devices for transdermal biosensing and drug delivery.Materials today. Bio · 2025Review
- Electrically conductive "SMART" hydrogels for on-demand drug delivery.Asian journal of pharmaceutical sciences · 2025Review
- Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review.ACS materials Au · 2025Review
- Leveraging Microneedles for Raised Scar Management.Polymers · 2025Review
- Microneedles for controlled and sustained intraocular drug delivery.NPG Asia materials · 2025Review
- Research progress and strategy of FGF21 for skin wound healing.Frontiers in medicine · 2025Review
- A Bibliometric Analysis of Microneedle-Mediated Drug Delivery: Trends, Hotspots, and Future Directions.Drug design, development and therapy · 2025Review
- Designing Multifunctional Microneedles in Biomedical Engineering: Materials, Methods, and Applications.International journal of nanomedicine · 2025Review
- Synergistic Strategies of Biomolecular Transport Technologies in Transdermal Healthcare Systems.Advanced healthcare materials · 2024Review
- Research Progress of Hydrogel Microneedles in Wound Management.ACS biomaterials science & engineering · 2024Review
- Microneedle-mediated nanomedicine to enhance therapeutic and diagnostic efficacy.Nano convergence · 2024Review
- Advancements in Skin-Mediated Drug Delivery: Mechanisms, Techniques, and Applications.Advanced healthcare materials · 2024Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A multifunctional system comprised of hyaluronic acid microneedles was developed as an effective transdermal delivery platform for rapid local delivery. The microneedles can regulate the filling amount on the tip, by controlling the concentration of hyaluronic acid solution. Ultrasonication induces dissolution of the HA microneedles via vibration of acoustic pressure, and AC iontophoresis improves the electrostatic force-driven diffusion of HA ions and rhodamine B. The effect of ultrasound on rhodamine release was analyzed in vitro using a gelatin hydrogel. The frequency and voltage dependence of the AC on the ion induction transfer was also evaluated experimentally. The results showed that the permeability of the material acts as a key material property. The delivery system based on ultrasonication and iontophoresis in microneedles increases permeation, thus resulting in shorter initial delivery time than that required by delivery systems based on passive or ultrasonication alone. This study highlights the significance of the combination between ultrasonic waves and iontophoresis for improving the efficiency of the microneedles, by shortening the reaction duration. We anticipate that this system can be extended to macromolecular and dependence delivery, based on drug response time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.