Evidence map›Paper›PMID 32029761›Full record

ArticleScientific reports2020

Formate dehydrogenase, ubiquinone, and cytochrome bd-I are required for peptidoglycan recognition protein-induced oxidative stress and killing in Escherichia coli.

Des R Kashyap, Dominik A Kowalczyk, Yue Shan, Chun-Kai Yang, Dipika Gupta, Roman Dziarski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Des R KashyapIndiana University School of Medicine-Northwest, Gary, IN, 46408, USA.
Dominik A KowalczykIndiana University School of Medicine-Northwest, Gary, IN, 46408, USA.
Yue ShanAntimicrobial Discovery Center, Northeastern University, Boston, MA, 02115, USA.
Chun-Kai YangIndiana University School of Medicine-Northwest, Gary, IN, 46408, USA.
Dipika GuptaIndiana University School of Medicine-Northwest, Gary, IN, 46408, USA.
Roman DziarskiIndiana University School of Medicine-Northwest, Gary, IN, 46408, USA. rdziar@iun.edu.ORCID http://orcid.org/0000-0002-1911-2104
Indiana University Northwest · USNortheastern University · US

Funding

Antibacterial activity of peptidoglycan recognition proteinsR01AI120962 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI DZIARSKI, ROMAN · 2016 to 2019
$1.6M
NIAID NIH HHS R01 AI120962
6 · The paper itself

Abstract

Mammalian Peptidoglycan Recognition Proteins (PGRPs) kill bacteria through induction of synergistic oxidative, thiol, and metal stress. PGRPs induce oxidative stress in bacteria through a block in the respiratory chain, which results in decreased respiration and incomplete reduction of oxygen (O

Indexed as

Host Microbial InteractionsAnimalsCarrier ProteinsCell LineCytochrome d GroupCytochromes bDrosophila melanogasterEscherichia coliEscherichia coli ProteinsFormate DehydrogenasesHumansHydrogen PeroxideMutationOxidation-ReductionOxidative StressRecombinant ProteinsCarrier ProteinsCytochrome d GroupCytochromes bEscherichia coli Proteinsformate dehydrogenase-OFormate DehydrogenasesHydrogen Peroxidepeptidoglycan recognition proteinRecombinant ProteinsUbiquinone

Identifiers

PMID32029761
PMCPMC7005000
OpenAlexW3005471862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.