ArticleScientific reports2020
Characterization and potential mechanisms of highly antibiotic tolerant VBNC Escherichia coli induced by low level chlorination.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 70 citations in OpenAlex.
- Transcriptomic insights on differential gene regulations in viable but non-culturable (VBNC) bacteria under chlorine and UV disinfection.BMC microbiology · 2026Article
- Bioelectrochemical detection of viable but non-culturable bacterial cells on screen-printed carbon electrodes.Biofilm · 2026Article
- Repeat Prolonged Chlorination at Low Dose Induces Chlorine Tolerance inEnvironment & health (Washington, D.C.) · 2026Article
- Identification, Characterization, and Ultrastructure Analysis of the Phenol-DegradingMicroorganisms · 2024Article
- Understanding the transition to viable but non-culturable state in Escherichia coli W3110: a comprehensive analysis of potential spectrochemical biomarkers.World journal of microbiology & biotechnology · 2024Article
- Characterization of viable but nonculturable state ofRoyal Society open science · 2024Article
- Effect of physicochemical and microbiological factors on the development of viable but non-culturable and resuscitation states of Vibrio cholerae.Archives of microbiology · 2024Article
- Quantitative Proteomic Analysis on the Slightly Acidic Electrolyzed Water Triggered Viable but Non-CulturableInternational journal of molecular sciences · 2023Article
- Current Perspectives on Viable but Non-Culturable Foodborne Pathogenic Bacteria: A Review.Foods (Basel, Switzerland) · 2023Review
- Screening ofMicroorganisms · 2023Article
- Overview of VBNC, a survival strategy for microorganisms.3 Biotech · 2022Review
- Transcriptome analysis and prediction of the metabolic state of stress-induced viable but non-culturable Bacillus subtilis cells.Scientific reports · 2022Article
- A Phage Receptor-Binding Protein as a Promising Tool for the Detection ofFrontiers in microbiology · 2022Article
- Application of the Swimming Pool Backwash Water Recovery System with the Use of Filter Tubes.Molecules (Basel, Switzerland) · 2021Article
- Herbicides Tolerance in aFrontiers in microbiology · 2021Article
- Copper Resistance Mediates Long-Term Survival ofFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Escherichia coli is an important pathogenic indicator in drinking water. Viable but non-culturable (VBNC) E. coli induced by low level chlorination was found to have higher antibiotic tolerance. The emerging of VBNC bacteria in drinking water systems is posing challenges to the control of bio-safety. It is necessary to study the underlying mechanisms of VBNC state E. coli under actual residual chlorine condition of drinking water pipe network. In this study, we investigated the changes of morphology and gene expressions that might present such state. The results indicated that the size of VBNC E. coli was not remarkably changed or recovered culturability under favorable environmental conditions. Results from transcriptomic analysis revealed that the regulated genes related to fimbrial-like adhesin protein, putative periplasmic pilin chaperone, regulators of the transcriptional regulation, antibiotic resistance genes and stress-induced genes, rendering VBNC cells more tolerant to adverse environmental conditions. In total of 16 genes were significantly up-regulated under the VBNC state, including three genes encoding toxic protein (ygeG, ibsD, shoB), indicating that VBNC E. coil was still a threat to human. The work is of great relevance in the context of better understanding this poorly understood physiological state.
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