Evidence map›Paper›PMID 32029751›Full record

ArticleScientific reports2020

Effect of Immune Activation during Early Gestation or Late Gestation on Inhibitory Markers in Adult Male Rats.

Tasnim Rahman, Cynthia Shannon Weickert, Lauren Harms, Crystal Meehan, Ulrich Schall, Juanita Todd, Deborah M Hodgson, Patricia T Michie, Tertia Purves-Tyson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Tasnim RahmanSchool of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Cynthia Shannon WeickertSchool of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Lauren HarmsSchool of Psychology, The University of Newcastle, Sydney, NSW, Australia.
Crystal MeehanSchool of Psychology, The University of Newcastle, Sydney, NSW, Australia.
Ulrich SchallPriority Centre for Brain and Mental Health Research, The University of Newcastle, Newcastle, NSW, Australia.
Juanita ToddSchool of Psychology, The University of Newcastle, Sydney, NSW, Australia.
Deborah M HodgsonSchool of Psychology, The University of Newcastle, Sydney, NSW, Australia.
Patricia T MichieSchool of Psychology, The University of Newcastle, Sydney, NSW, Australia.
Tertia Purves-TysonSchool of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. t.purves-tyson@neura.edu.au.
University of Newcastle Australia · AUHunter Medical Research Institute · AUUNSW Sydney · AUNeuroscience Research Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

People with schizophrenia exhibit deficits in inhibitory neurons and cognition. The timing of maternal immune activation (MIA) may present distinct schizophrenia-like phenotypes in progeny. We investigated whether early gestation [gestational day (GD) 10] or late gestation (GD19) MIA, via viral mimetic polyI:C, produces deficits in inhibitory neuron indices (GAD1, PVALB, SST, SSTR2 mRNAs) within cortical, striatal, and hippocampal subregions of male adult rat offspring. In situ hybridisation revealed that polyI:C offspring had: (1) SST mRNA reductions in the cingulate cortex and nucleus accumbens shell, regardless of MIA timing; (2) SSTR2 mRNA reductions in the cortex and striatum of GD19, but not GD10, MIA; (3) no alterations in cortical or striatal GAD1 mRNA of polyI:C offspring, but an expected reduction of PVALB mRNA in the infralimbic cortex, and; (4) no alterations in inhibitory markers in hippocampus. Maternal IL-6 response negatively correlated with adult offspring SST mRNA in cortex and striatum, but not hippocampus. These results show lasting inhibitory-related deficits in cortex and striatum in adult offspring from MIA. SST downregulation in specific cortical and striatal subregions, with additional deficits in somatostatin-related signalling through SSTR2, may contribute to some of the adult behavioural changes resulting from MIA and its timing.

Indexed as

AnimalsBehavior, AnimalBiomarkersCerebral CortexCorpus StriatumDisease Models, AnimalDown-RegulationFemaleGlutamate DecarboxylaseHippocampusHumansInterleukin-6InterneuronsMaleNeural InhibitionPoly I-CBiomarkersGlutamate Decarboxylaseglutamate decarboxylase 1Il6 protein, ratInterleukin-6Poly I-CReceptors, SomatostatinSomatostatinSstr2 protein, rat

Identifiers

PMID32029751
PMCPMC7004984
OpenAlexW3004698232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.