Evidence map›Paper›PMID 32029733›Full record

ArticleNature communications2020

Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome.

Daniel Fox, Anukriti Mathur, Yansong Xue, Yunqi Liu, Wei Hong Tan, Shouya Feng, Abhimanu Pandey, Chinh Ngo, Jenni A Hayward, Ines I Atmosukarto and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 89 citations in OpenAlex.

  1. Article
  2. Virulence · 2026
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  3. Review
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  5. Review
  6. Review
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  8. Review
  9. Article
  10. Article
  11. DAMP-ing IBD: Extinguish the Fire and Prevent Smoldering.Digestive diseases and sciences · 2025
    Review
  12. Article
  13. Article
  14. Revealing the Mechanism of NLRP3 Inflammatory Pathway Activation through KInternational journal of molecular sciences · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 4 countries.

Daniel Fox *Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.ORCID http://orcid.org/0000-0003-0271-2776
Anukriti Mathur *Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.ORCID http://orcid.org/0000-0002-7004-301X
Yansong XueDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Yunqi LiuDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Wei Hong TanDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Shouya FengDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Abhimanu PandeyDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Chinh NgoDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Jenni A HaywardDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Ines I AtmosukartoLipotek Pty Ltd. The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Jason D PriceLipotek Pty Ltd. The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Matthew D JohnsonResearch School of Biology, The Australian National University, Canberra, Australia.
Nadja JessbergerDepartment of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, Oberschleißheim, Germany.
Avril A B RobertsonSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia.ORCID http://orcid.org/0000-0002-9652-8357
Gaetan BurgioDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.ORCID http://orcid.org/0000-0002-7434-926X
David C TscharkeDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.ORCID http://orcid.org/0000-0001-6825-9172
Edward M FoxDepartment of Applied Sciences, Northumbria University, Newcastle Upon Tyne, UK.
Denisse L LeytonResearch School of Biology, The Australian National University, Canberra, Australia.
Nadeem O KaakoushSchool of Medical Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia.
Erwin MärtlbauerDepartment of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, Oberschleißheim, Germany.ORCID http://orcid.org/0000-0003-3390-8173
Stephen H LepplaMicrobial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Si Ming ManDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia. siming.man@anu.edu.au.ORCID http://orcid.org/0000-0002-5079-2857
Australian National University · AULudwig-Maximilians-Universität München · DENational Institutes of Health · USNorthumbria University · GBThe University of Queensland · AUUNSW Sydney · AU

Funding

Pathophysiological Actions of the Anthrax ToxinsZIAAI001032 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LEPPLA, STEPHEN · 2009 to 2025
$10.9M
6 · The paper itself

Abstract

Inflammasomes are important for host defence against pathogens and homeostasis with commensal microbes. Here, we show non-haemolytic enterotoxin (NHE) from the neglected human foodborne pathogen Bacillus cereus is an activator of the NLRP3 inflammasome and pyroptosis. NHE is a non-redundant toxin to haemolysin BL (HBL) despite having a similar mechanism of action. Via a putative transmembrane region, subunit C of NHE initiates binding to the plasma membrane, leading to the recruitment of subunit B and subunit A, thus forming a tripartite lytic pore that is permissive to efflux of potassium. NHE mediates killing of cells from multiple lineages and hosts, highlighting a versatile functional repertoire in different host species. These data indicate that NHE and HBL operate synergistically to induce inflammation and show that multiple virulence factors from the same pathogen with conserved function and mechanism of action can be exploited for sensing by a single inflammasome.

Indexed as

AnimalsBacillus cereusBacterial ProteinsCell LineEnterotoxinsFemaleHemolysin ProteinsHost Microbial InteractionsHost SpecificityHumansInflammasomesMaleMiceMice, Inbred C57BLMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinBacterial Proteinsenterotoxin, Bacillus cereusEnterotoxinshemolysin BL protein, BacillusHemolysin ProteinsInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinVirulence Factors

Identifiers

PMID32029733
PMCPMC7005308
OpenAlexW3004459705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.