Evidence map›Paper›PMID 32029712›Full record

ArticleNature communications2020

Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis.

Trinidad Montero-Melendez, Ai Nagano, Claude Chelala, Andrew Filer, Christopher D Buckley, Mauro Perretti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. MC1R determines healing outcomes in acute and chronic cutaneous wounds.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Cellular senescence in kidney diseases.Chinese medical journal · 2025
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Musculoskeletal imaging of senescence.Skeletal radiology · 2024
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Trinidad Montero-MelendezThe William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK. t.monteromelendez@qmul.ac.uk.ORCID http://orcid.org/0000-0002-3563-376X
Ai NaganoBarts Cancer Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.ORCID http://orcid.org/0000-0002-2354-660X
Claude ChelalaBarts Cancer Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Andrew FilerNIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Institute of Inflammation and Ageing, Birmingham, UK.ORCID http://orcid.org/0000-0001-8164-6249
Christopher D BuckleyNIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Institute of Inflammation and Ageing, Birmingham, UK.ORCID http://orcid.org/0000-0001-6924-6402
Mauro PerrettiThe William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK. m.perretti@qmul.ac.uk.ORCID http://orcid.org/0000-0003-2068-3331
Queen Mary University of London · GBUniversity Hospitals Birmingham NHS Foundation Trust · GB

Funding

Arthritis Research UK 21274Medical Research Council MR/N026977/1Medical Research Council MR/S025308/1RCUK | Medical Research Council (MRC) MR/K013068/1
6 · The paper itself

Abstract

Rheumatoid arthritis affects individuals commonly during the most productive years of adulthood. Poor response rates and high costs associated with treatment mandate the search for new therapies. Here we show that targeting a specific G-protein coupled receptor promotes senescence in synovial fibroblasts, enabling amelioration of joint inflammation. Following activation of the melanocortin type 1 receptor (MC

Indexed as

alpha-MSHAnimalsArthritis, ExperimentalArthritis, RheumatoidCells, CulturedCellular SenescenceFibroblastsGenetic VariationHumansImidazolesMaleMetabolic Networks and PathwaysMiceMice, Inbred C57BLMice, KnockoutReceptor, Melanocortin, Type 1alpha-MSHBMS-470539ImidazolesMC1R protein, humanReceptor, Melanocortin, Type 1Receptors, Notch

Identifiers

PMID32029712
PMCPMC7005314
OpenAlexW3004610131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.