Evidence map›Paper›PMID 32029627›Full record

ArticleScience (New York, N.Y.)2020

Mosquito heat seeking is driven by an ancestral cooling receptor.

Chloe Greppi, Willem J Laursen, Gonzalo Budelli, Elaine C Chang, Abigail M Daniels, Lena van Giesen, Andrea L Smidler, Flaminia Catteruccia, Paul A Garrity

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 153 citations in OpenAlex.

  1. Article
  2. Article
  3. Sexually Dimorphic Visual Processing in the Yellow-Fever Mosquito,bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Optogenetic Analysis of Behavior in the Mosquito Aedes aegypti.Journal of visualized experiments : JoVE · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. The sensory biology of mosquito gustation.Current opinion in neurobiology · 2026
    Review
  10. Article
  11. Optogenetic Analysis of Behavior in the MosquitobioRxiv : the preprint server for biology · 2026
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Time-of-day modulation in mosquito response persistence to carbon dioxide is controlled by Pigment-Dispersing Factor.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Review
  18. Article
  19. A single-nucleus transcriptomic atlas of the adultbioRxiv : the preprint server for biology · 2025
    Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chloe Greppi *Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA.ORCID 0000-0001-5827-3448
Willem J Laursen *Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA.ORCID 0000-0002-0952-317X
Gonzalo BudelliDepartment of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA.ORCID 0000-0002-2157-5511
Elaine C ChangDepartment of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA.ORCID 0000-0002-9952-778X
Abigail M DanielsDepartment of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA.ORCID 0000-0002-6542-1960
Lena van GiesenDepartment of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA.
Andrea L SmidlerDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-3281-1161
Flaminia CatterucciaDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0003-3295-6683
Paul A GarrityDepartment of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA. pgarrity@brandeis.edu.ORCID 0000-0002-8274-6564
Brandeis University · USHarvard University · US

Funding

Quantitative Neuroscience: Tools for Bridging Levels of AnalysisT32NS007292 · NINDS · BRANDEIS UNIVERSITY · PI GINA G TURRIGIANO · 1986 to 2026
$12.7M
GENETIC AND BIOCHEMICAL MECHANISMS OF REGULATIONT32GM007122 · NIGMS · BRANDEIS UNIVERSITY · PI LOVETT, SUSAN THOMAS · 1985 to 2020
$7.5M
Unraveling the polymodal behavior of sensory transduction receptorsR01AI122802 · NIAID · BRANDEIS UNIVERSITY · PI GARRITY, PAUL · 2016 to 2020
$2.3M
Developing Homology-Independent Targeted Insertion (HITI) toolkits for molecular genetic manipulation of Drosophila melanogaster and Anopheles gambiaeR21AI140018 · NIAID · BRANDEIS UNIVERSITY · PI GARRITY, PAUL · 2018 to 2019
$460k
New roles for chemoreceptor paralogues in DrosophilaF32GM113318 · NIGMS · BRANDEIS UNIVERSITY · PI BUDELLI, GONZALO · 2015 to 2017
$109k
Ionotropic Receptor Function in Anopheles gambiaeF31AI133945 · NIAID · BRANDEIS UNIVERSITY · PI GREPPI, CHLOE · 2018 to 2019
$61k
Howard Hughes Medical InstituteNIAID NIH HHS F31 AI133945NIAID NIH HHS R01 AI122802NIAID NIH HHS R21 AI140018NIGMS NIH HHS F32 GM113318NIGMS NIH HHS T32 GM007122NINDS NIH HHS T32 NS007292
6 · The paper itself

Abstract

Mosquitoes transmit pathogens that kill >700,000 people annually. These insects use body heat to locate and feed on warm-blooded hosts, but the molecular basis of such behavior is unknown. Here, we identify ionotropic receptor IR21a, a receptor conserved throughout insects, as a key mediator of heat seeking in the malaria vector

Indexed as

Body TemperatureEvolution, MolecularHot TemperatureAnimalsAnophelesBloodFemaleHost-Seeking BehaviorMiceMutationReceptors, Ionotropic GlutamateThermoreceptorsReceptors, Ionotropic Glutamate

Identifiers

PMID32029627
PMCPMC8092076
OpenAlexW3004459549

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.