Evidence map›Paper›PMID 32029589›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Defective HIV-1 proviruses produce viral proteins.

Hiromi Imamichi, Mindy Smith, Joseph W Adelsberger, Taisuke Izumi, Francesca Scrimieri, Brad T Sherman, Catherine A Rehm, Tomozumi Imamichi, Alice Pau, Marta Catalfamo and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers.

0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed
19.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

190 citing papers in PubMed, 245 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. The immunophenotype and proviral landscape of HIV-infected CD4 T cells during antiretroviral therapy.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. The HIV reservoir landscape in elite controllers.Current opinion in HIV and AIDS · 2026
    Review
  17. Review
  18. Article
  19. Review
  20. Article

130 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Hiromi ImamichiLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Mindy SmithLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Joseph W AdelsbergerApplied and Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Taisuke IzumiApplied and Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Francesca ScrimieriApplied and Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Brad T ShermanApplied and Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Catherine A RehmLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Tomozumi ImamichiApplied and Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Alice PauDivision of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Marta CatalfamoDepartment of Microbiology and Immunology, Georgetown University School of Medicine, Washington, DC 20057.
Anthony S FauciLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; afauci@niaid.nih.gov clane@niaid.nih.gov.
H Clifford LaneLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; afauci@niaid.nih.gov clane@niaid.nih.gov.
Frederick National Laboratory for Cancer Research · USNational Institutes of Health · USNational Institute of Allergy and Infectious Diseases · USGeorgetown University · US

Funding

Pathogenesis and Treatment of HIV InfectionZIAAI000585 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LANE, CLIFFORD · 2009 to 2025
$26.8M
NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

HIV-1 proviruses persist in the CD4

Indexed as

CD4-Positive T-LymphocytesHIV-1HIV InfectionsHumansLeukocytes, MononuclearMaleMiddle AgedProvirusesViral ProteinsViral ProteinsHIVimmune activationprovirus

Identifiers

PMID32029589
PMCPMC7035625
OpenAlexW3005267901

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.