ArticleProceedings of the National Academy of Sciences of the United States of America2020
Short-wavelength optoacoustic spectroscopy based on water muting.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Photoacoustic Noninvasive Blood Glucose Monitoring: A Review of Systems and Strategies for Robust Glucose Concentration Estimation, with Perspectives on Miniaturization and Wearability.Sensors (Basel, Switzerland) · 2026Review
- Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Deep tissue sensing of chiral molecules using polarization-enhanced photoacoustics.Science advances · 2025Article
- Deep learning methods hold promise for light fluence compensation in three-dimensional optoacoustic imaging.Journal of biomedical optics · 2022Article
- Terahertz optoacoustic detection of aqueous salt solutions.iScience · 2022Article
- Non-Invasive Monitoring of Human Health by Photoacoustic Spectroscopy.Sensors (Basel, Switzerland) · 2022Review
- Terahertz pump-probe of liquid water at 12.3 THz.Physical chemistry chemical physics : PCCP · 2022Article
- Reporter gene-based optoacoustic imaging of E. coli targeted colon cancer in vivo.Scientific reports · 2021Article
- Single-wavelength water muted photoacoustic system for detecting physiological concentrations of endogenous molecules.Biomedical optics express · 2021Article
- Short-wavelength optoacoustic spectroscopy based on water muting.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infrared (IR) optoacoustic spectroscopy can separate a multitude of molecules based on their absorption spectra. However, the technique is limited when measuring target molecules in aqueous solution by strong water absorption at IR wavelengths, which reduces detection sensitivity. Based on the dependence of optoacoustic signal on the temperature of the probed medium, we introduce cooled IR optoacoustic spectroscopy (CIROAS) to mute water contributions in optoacoustic spectroscopy. We showcase that spectral measurements of proteins, lipids, and glucose in the short-wavelength IR region, performed at 4 °C, lead to marked sensitivity improvements over conventional optoacoustic or IR spectroscopy. We elaborate on the dependence of optoacoustic signals on water temperature and demonstrate polarity changes in the recorded signal at temperatures below 4 °C. We further elucidate the dependence of the optoacoustic signal and the muting temperature on sample concentration and demonstrate that changes in these dependences enable quantification of the solute concentration. We discuss how CIROAS may enhance abilities for molecular sensing in the IR.
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