Evidence map›Paper›PMID 32029445›Full record

ArticleThe European respiratory journal2020

Neuropeptide regulation of secretion and inflammation in human airway gland serous cells.

Derek B McMahon, Ryan M Carey, Michael A Kohanski, Charles C L Tong, Peter Papagiannopoulos, Nithin D Adappa, James N Palmer, Robert J Lee

Open access · bronzeAbstract read
In one paragraph

Article in The European respiratory journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 31 citations in OpenAlex.

  1. Structural and cellular mechanisms of mucus plugging in the larger airways.Chinese medical journal pulmonary and critical care medicine · 2026
    Review
  2. Review
  3. Review
  4. Article
  5. Middle Turbinate Resection Versus its Preservation in Patients with Chronic Polypoid Rhinosinusitis Undergoing Endoscopic Sinus Surgery.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. PAR-2-activated secretion by airway gland serous cells: role for CFTR and inhibition byAmerican journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  18. [Antimicrobial peptides and proteins in chronic rhinosinusitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Derek B McMahonDept of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Ryan M CareyDept of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Michael A KohanskiDept of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Charles C L TongDept of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-4471-5134
Peter PapagiannopoulosDept of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Nithin D AdappaDept of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
James N PalmerDept of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Robert J LeeDept of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0001-5826-6686
University of Pennsylvania · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6M
Bitter and sweet taste receptor physiology in airway ciliated cellsR01DC016309 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI LEE, ROBERT J. · 2018 to 2022
$2.1M
Intersections of bitter taste receptor (T2R) and toll-like receptor (TLR) signaling in airway epithelial cell innate immunityR21AI137484 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI LEE, ROBERT J. · 2018 to 2019
$443k
NCI NIH HHS P30 CA016520NIAID NIH HHS P30 AI045008NIAID NIH HHS R21 AI137484NIDCD NIH HHS R01 DC016309
6 · The paper itself

Abstract

Airway submucosal gland serous cells are sites of expression of the cystic fibrosis transmembrane conductance regulator (CFTR) and are important for fluid secretion in conducting airways. To elucidate how neuropeptides regulate serous cells, we tested if human nasal turbinate serous cells secrete bicarbonate (HCO

Indexed as

Cyclic AMPCystic Fibrosis Transmembrane Conductance RegulatorChloridesHumansInflammationMucusRespiratory MucosaVasoactive Intestinal PeptideChloridesCyclic AMPCystic Fibrosis Transmembrane Conductance RegulatorVasoactive Intestinal Peptide

Identifiers

PMID32029445
PMCPMC7166175
OpenAlexW3004916316

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.