Evidence map›Paper›PMID 32029377›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2020

Comparison between conventional and HD-tDCS of the right inferior frontal gyrus in children and adolescents with ADHD.

Carolin Breitling, Tino Zaehle, Moritz Dannhauer, Jana Tegelbeckers, Hans-Henning Flechtner, Kerstin Krauel

Registry-linked trialOpen access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05832060 (Comparing the Efficacy of tDCS and tRNS to Improve Reading Skills in Children and Adolescents With Dyslexia), which is not on this map. Cited by 39 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 6 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05832060 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Comparing the Efficacy of tDCS and tRNS to Improve Reading Skills in Children and Adolescents With Dyslexia

TypeinterventionalSponsorBambino Gesù Hospital and Research InstituteRan2023 to 2025Enrolled24ConditionsDevelopmental DyslexiaArmsActive tDCS, Active tRNS, Sham tRNS or tDCS
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 6 syntheses or guidelines pooled it, 71 citations in OpenAlex.

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  17. Neuromodulation as a Potential Intervention for Children With Attention-Deficit/Hyperactivity Disorder.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2025
    Article
  18. tDCS and neurofeedback in ADHD treatment.Frontiers in systems neuroscience · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Carolin BreitlingDepartment of Child and Adolescent Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany. Electronic address: carolin.breitling@med.ovgu.de.
Tino ZaehleDepartment of Neurology, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences, Otto-von-Guericke University, Magdeburg, Germany. Electronic address: tino.zaehle@med.ovgu.de.
Moritz DannhauerScientific Computing and Imaging Institute, Center for Integrated Biomedical Computing, University of Utah, Salt Lake City, UT, USA. Electronic address: moritz@sci.utah.edu.
Jana TegelbeckersDepartment of Child and Adolescent Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: jana.tegelbeckers@northwestern.edu.
Hans-Henning FlechtnerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany. Electronic address: hans-henning.flechtner@med.ovgu.de.
Kerstin KrauelDepartment of Child and Adolescent Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences, Otto-von-Guericke University, Magdeburg, Germany. Electronic address: kerstin.krauel@med.ovgu.de.
Center for Behavioral Brain Sciences · DEOtto-von-Guericke University Magdeburg · DENorthwestern University · USUniversity of Utah · US

Funding

TRD - VisualizationP41GM103545 · NIGMS · UNIVERSITY OF UTAH · PI JURRUS, ELIZABETH · 2012 to 2019
$9.7M
NIGMS NIH HHS P41 GM103545
6 · The paper itself

Abstract

objectiveTo investigate whether the effects of HD-tDCS and conventional tDCS of the right IFG are superior to the effects of sham stimulation for the improvement of working memory performance in ADHD.

methods15 ADHD patients between 10 and 16 years underwent three tDCS sessions in which conventional, HD and sham tDCS of the right IFG were applied. In all sessions a 2-back working memory task was solved and EEG was recorded. Baseline data were assessed from 15 age matched healthy controls.

resultsIn ADHD patients, increased positive values of P300 and N200 mean amplitudes were found after conventional and HD-tDCS. Thus, both components were more in resemblance to ERPs in healthy controls. Behavioral performance was not generally influenced by tDCS but effects of HD-tDCS depended on individual hyperactive/impulsive symptom load. The rate of responders for HD-tDCS was equivalent to the responder rate for conventional tDCS.

conclusionsERP data indicate that HD-tDCS is equally suitable as conventional tDCS for the recruitment of the right IFG in the context of working memory processing. SIGNIFICANCE: HD-tDCS of the right IFG is a promising approach for neuromodulation in ADHD but further research is necessary to develop adaptations that produce reliable behavioral benefits.

Indexed as

AdolescentAttention Deficit Disorder with HyperactivityChildElectroencephalographyEvent-Related Potentials, P300Evoked PotentialsFemaleHumansMaleMemory, Short-TermPrefrontal CortexPsychomotor PerformanceTranscranial Direct Current StimulationAttention deficit hyperactivity disorder (ADHD)High definition transcranial direct current stimulation (HD-tDCS)n-back taskRight inferior frontal gyrus (IFG)Transcranial direct current stimulation (tDCS)Working memory

Identifiers

PMID32029377
PMCPMC7250280
OpenAlexW3001775167

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.