ArticlePediatric neurology2020
Tic Disorders are Associated With Lower Child and Parent Quality of Life and Worse Family Functioning.
Article in Pediatric neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Psychosocial experiences in youth with Tourette syndrome: a systematic review and meta-synthesis.European child & adolescent psychiatry · 2024Pooled it
- Tackle your Tics, a brief intensive group-based exposure treatment for young people with tics: results of a randomised controlled trial.European child & adolescent psychiatry · 2024Trial
- Childhood Predictors of Long-Term Tic Severity and Tic Impairment in Tourette's Disorder.Behavior therapy · 2022Trial
- A Cross-Sectional Study Utilizing Online Support Communities for Tic Disorders: the Association between Participation Duration and Quality of Life in Children with Tic Disorders and Their Caregivers.European journal of pediatrics · 2026Article
- Clinical Features, Mechanisms, and Management of Anxiety in Youth with Tic Disorders: A Narrative Review.Neuropsychiatric disease and treatment · 2026Review
- Article
- Metabolic abnormalities of the cortico‑striato‑thalamo‑cortical circuit of rats with tic disorder.Molecular medicine reports · 2025Article
- Medicinal cannabis for tics in adolescents with Tourette syndrome.BJPsych open · 2025Article
- Coprophenomena Associated With Worse Individual and Family Function for Youth With Tourette Syndrome: A Cross-Sectional Study.Neurology. Clinical practice · 2025Article
- Family functioning mediation in tic severity and quality of life for children with Tourette syndrome.World journal of psychiatry · 2024Article
- Bedtime Regularity and Sleep Sufficiency in Children With Tourette Syndrome.Pediatric neurology · 2024Article
- Vitamin D3 improves iminodipropionitrile-induced tic-like behavior in rats through regulation of GDNF/c-Ret signaling activity.European child & adolescent psychiatry · 2024Article
- Factors linked to prognosis in children with provisional tic disorder: a prospective cohort study.European journal of pediatrics · 2024Article
- Brief youth self-report screener for tics: Can a subscale of the Motor tic, Obsession and compulsion, and Vocal tic Evaluation Survey (MOVES) identify tic disorders in youth?Evidence-based practice in child and adolescent mental health · 2023Article
- Sociodemographic and clinical characteristics of children with tic disorders and behavioral problems: A real-world study and development of a prediction model.BMC pediatrics · 2023Article
- Article
- Validation of the Diagnostic Interview Schedule for Children (DISC-5) Tic Disorder and Attention-Deficit/Hyperactivity Disorder Modules.Evidence-based practice in child and adolescent mental health · 2023Article
- Electrophysiological signatures of inhibitory control in children with Tourette syndrome and attention-deficit/hyperactivity disorder.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- A preliminary study of comprehensive behavioral intervention for tics in Chinese children with chronic tic disorder or Tourette syndrome.Frontiers in psychiatry · 2022Article
- Implementation of the Mini-Child Tourette Syndrome Impairment Scale: Relationships to Symptom Severity and Treatment Decisions.Journal of child neurology · 2021Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveChronic tic disorders occur in approximately 3% of children. Neuropsychiatric symptoms of attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, anxiety, and depression are common. We evaluated the impact of tic disorders and comorbid symptoms on individual and parent quality of life and family functioning.
methodIn two cross-sectional studies children with tic disorders were enrolled at the University of Rochester or the University of South Florida; data were pooled for analyses. Control subjects were enrolled at the University of Rochester. We compared quality of life and function in youth and families with and without tic disorders. We evaluated the associations between comorbid symptoms and individual quality of life and family impact in youth with tic disorders using multiple regression analyses.
resultsWe enrolled 205 youths with tic disorders and 100 control subjects. Psychosocial (P < 0.0001) and physical (P < 0.0001) quality of life were lower in individuals with tic disorders compared with controls. Severity of attention-deficit/hyperactivity disorder (P < 0.0001) and depression (P = 0.046) symptoms were associated with lower psychosocial quality of life in youth with tic disorders. Families of youths with tic disorders had worse parent quality of life (P < 0.001) and family functioning (P < 0.001) than control families. Severity of attention-deficit/hyperactivity disorder (P < 0.0001), obsessive-compulsive disorder (P = 0.0004), and depression (P = 0.01) symptoms were associated with predicted worse family impact.
conclusionYouths with tic disorders had lower individual and parent quality of life and worse family functioning than controls. The impact of tic disorders on the family may have significant implications for approaches to providing comprehensive care to these families.
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Registered trials
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