ArticleAnalytica chimica acta2020
Electrophysiology-based stratification of pancreatic tumorigenicity by label-free single-cell impedance cytometry.
Article in Analytica chimica acta, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 67 citations in OpenAlex.
- Code-multiplexed multi-frequency impedance cytometry with a unified deep-unfolding network.Microsystems & nanoengineering · 2026Article
- Position-Independent Particle Sizing in High-Precision Impedance Cytometry via Full-Waveform Feature Calibration.Electrophoresis · 2026Article
- Cell-Based Immuno-Biosensors Using Microfluidics.Sensors (Basel, Switzerland) · 2026Review
- In situ detection of dead cells from live cells via a DC plus low frequency AC resistive pulse sensor.Biomedical microdevices · 2026Article
- On-Chip Integration of Impedance Cytometry for Inline Optimization of Dielectrophoretic Separations on Multiple Cellular Biophysical Metrics.ACS sensors · 2025Article
- Neural Network-Enabled Multiparametric Impedance Signal Templating for High throughput Single-Cell Deformability Cytometry Under Viscoelastic Extensional Flows.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Analysis of Cell Dielectrophoretic Properties Using Isomotive Creek-Gap Electrode Device.Sensors (Basel, Switzerland) · 2024Article
- Single-cell electro-mechanical shear flow deformability cytometry.Microsystems & nanoengineering · 2024Article
- Microfluidic-Based Electrical Operation and Measurement Methods in Single-Cell Analysis.Sensors (Basel, Switzerland) · 2024Review
- Review
- Supervised learning on impedance cytometry data for label-free biophysical distinction of pancreatic cancer cells versus their associated fibroblasts under gemcitabine treatment.Biosensors & bioelectronics · 2023Article
- Multichannel impedance cytometry downstream of cell separation by deterministic lateral displacement to quantify macrophage enrichment in heterogeneous samples.Advanced materials technologies · 2023Article
- Label-Free Microfluidic Impedance Cytometry for Acrosome Integrity Assessment of Boar Spermatozoa.Biosensors · 2022Article
- Single-cell assessment of the modulation of macrophage activation by ex vivo intervertebral discs using impedance cytometry.Biosensors & bioelectronics · 2022Article
- Review
- On-chip microfluidic buffer swap of biological samples in-line with downstream dielectrophoresis.Electrophoresis · 2022Article
- Modified Red Blood Cells as Multimodal Standards for Benchmarking Single-Cell Cytometry and Separation Based on Electrical Physiology.Analytical chemistry · 2022Article
- A Label-Free Electrical Impedance Spectroscopy for Detection of Clusters of Extracellular Vesicles Based on Their Unique Dielectric Properties.Biosensors · 2022Article
- A label-free and low-power microelectronic impedance spectroscopy for characterization of exosomes.PloS one · 2022Article
- Recent Advances in Electrical Impedance Sensing Technology for Single-Cell Analysis.Biosensors · 2021Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer lacking specific biomarkers that can be correlated to disease onset, promotion and progression. To assess whether tumor cell electrophysiology may serve as a marker for PDAC tumorigenicity, we use multi-frequency impedance cytometry at high throughput (∼350 cells/s) to measure the electrical phenotype of single PDAC tumor cells from xenografts, which are derived from primary pancreatic tumors versus those from liver metastases of different patients. A novel phase contrast metric based on variations in the high and low frequency impedance phase responses that is related to electrophysiology of the cell interior is found to be systematically altered as a function of tumorigenicity. PDAC cells of higher tumorigenicity exhibited lowered interior conductivity and enhanced permittivity, which is validated by the dielectrophoresis on the respective cell types. Using genetic analysis, we suggest the role of dysregulated Na
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.