Evidence map›Paper›PMID 32028989›Full record

ArticleJournal of neuroinflammation2020

Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1

Lukasz Wlodarek, Feng Cao, Faisal J Alibhai, Adam Fekete, Nima Noyan, Stephanie W Tobin, Tina B Marvasti, Jun Wu, Shu-Hong Li, Richard D Weisel and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 32 citations in OpenAlex.

  1. Young Sca-1Journal of nanobiotechnology · 2023
    Article
  2. Cranial irradiation induces cognitive decline associated with altered dendritic spine morphology in the young rat hippocampus.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022
    Article
  3. Article
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  5. Identification and functional characterization of CD133Molecular and cellular biochemistry · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Lukasz WlodarekToronto General Hospital Research Institute, University Health Network, Toronto Medical Discovery Tower, Room 3-702, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.
Feng CaoDepartment of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Faisal J AlibhaiToronto General Hospital Research Institute, University Health Network, Toronto Medical Discovery Tower, Room 3-702, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.
Adam FeketeProgram in Neurosciences & Mental Health, SickKids Research Institute, Floor 5, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.
Nima NoyanToronto General Hospital Research Institute, University Health Network, Toronto Medical Discovery Tower, Room 3-702, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.
Stephanie W TobinToronto General Hospital Research Institute, University Health Network, Toronto Medical Discovery Tower, Room 3-702, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.
Tina B MarvastiToronto General Hospital Research Institute, University Health Network, Toronto Medical Discovery Tower, Room 3-702, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.
Jun WuToronto General Hospital Research Institute, University Health Network, Toronto Medical Discovery Tower, Room 3-702, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.
Shu-Hong LiToronto General Hospital Research Institute, University Health Network, Toronto Medical Discovery Tower, Room 3-702, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.
Richard D WeiselToronto General Hospital Research Institute, University Health Network, Toronto Medical Discovery Tower, Room 3-702, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.
Lu-Yang WangDepartment of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. luyang.wang@utoronto.ca.
Zhengping JiaDepartment of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. zhengping.jia@sickkids.ca.
Ren-Ke LiToronto General Hospital Research Institute, University Health Network, Toronto Medical Discovery Tower, Room 3-702, 101 College Street, Toronto, Ontario, M5G 1L7, Canada. renkeli@uhnresearch.ca.ORCID http://orcid.org/0000-0002-8584-5736
University Health Network · CAUniversity of Toronto · CAHospital for Sick Children · CA

Funding

CIHR 332652Ontario Research Fund RE07-010
6 · The paper itself

Abstract

backgroundRadiotherapy is widely used and effective for treating brain tumours, but inevitably impairs cognition as it arrests cellular processes important for learning and memory. This is particularly evident in the aged brain with limited regenerative capacity, where radiation produces irreparable neuronal damage and activation of neighbouring microglia. The latter is responsible for increased neuronal death and contributes to cognitive decline after treatment. To date, there are few effective means to prevent cognitive deficits after radiotherapy.

methodsHere we implanted hematopoietic stem cells (HSCs) from young or old (2- or 18-month-old, respectively) donor mice expressing green fluorescent protein (GFP) into old recipients and assessed cognitive abilities 3 months post-reconstitution.

resultsRegardless of donor age, GFP

conclusionOur results suggest aged peripherally derived microglia-like cells may exacerbate cognitive impairments after radiotherapy, whereas young microglia-like cells are polarized to a reparative phenotype in the irradiated brain, particularly in neural circuits associated with rewards, learning, and memory. These findings present a proof-of-principle for effectively reinstating central cognitive function of irradiated brains with peripheral stem cells from young donor bone marrow.

Indexed as

Hematopoietic Stem Cell TransplantationAnimalsBehavior, AnimalCognitive DysfunctionDendritic SpinesHippocampusHumansLong-Term PotentiationMaze LearningMemoryMiceNeuronsRadiotherapyRecovery of FunctionSpinocerebellar AtaxiasTreatment OutcomeAgingBone marrow stem cellsLearning and memoryMicrogliaRadiotherapy

Identifiers

PMID32028989
PMCPMC7006105
OpenAlexW3006699875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.