Evidence map›Paper›PMID 32028827›Full record

ArticleCell adhesion & migration2020

Thymol alleviates AGEs-induced podocyte injury by a pleiotropic effect via NF-κB-mediated by RhoA/ROCK signalling pathway.

Qinglian Wang, Zhenwei Shen, Guanghui Qi, Yanfang Zhao, Hongge Zhang, Rong Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell adhesion & migration, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Use of Monoterpenes as Potential Therapeutics in Diabetes Mellitus: A Prospective Review.Advances in pharmacological and pharmaceutical sciences · 2023
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Qinglian WangDepartment of Nephrology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
Zhenwei ShenDepartment of Biostatistics, WuXi Clinical Development Service (Shanghai) Co., Ltd, Shanghai, China.
Guanghui QiDepartment of Urological Surgery, The First Hospital of Zibo, Shandong, China.
Yanfang ZhaoDepartment of Nephrology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
Hongge ZhangDepartment of Urological Surgery, Tengzhou Hospital of Traditional Chinese Medicine, Zaozhuang, China.
Rong WangDepartment of Nephrology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
Shandong Provincial Hospital · CNCentral Hospital of Zibo · CNShandong University · CNWuXi AppTec (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advanced glycation end products (AGE) are those of the most powerful pathogenic factors that related to diabetic complications. In our study, we investigated the beneficial effects of thymol on AGE induced cell injury and apoptosis in human podocytes (HPCs) and attempted to clarify its mechanisms. Our results revealed that stimulation with AGE could significantly activate RhoA/NF-κB pathway. Results showed thymol could markedly suppress inflammatory responses, cell apoptosis and disordered cytoskeleton. Also thymol restored the expression of podocin, restrained migration capacity. Western blot analysis indicated that it could restore the expression of RhoA, ROCK and vimentin, nephrin, podocin and p65 and IκBα phosphorylation. Moreover, si-RhoA also suppressed the expression of pro-inflammatory cytokines, ROCK, and vimentin and the phosphorylation of p65 and IκBα. In conclusion, thymol inhibits AGE-induced cell injury in HPCs by suppressing the RhoA-NF-κB pathway and may be apromising therapeutic agent.

Indexed as

Signal TransductionCell LineCell MovementCell SurvivalCytokinesCytoskeletonGlycation End Products, AdvancedHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsNF-kappa BPodocytesProtective AgentsrhoA GTP-Binding Proteinrho-Associated KinasesRNA, Small InterferingCytokinesGlycation End Products, AdvancedIntracellular Signaling Peptides and ProteinsMembrane ProteinsnephrinNF-kappa BNPHS2 proteinProtective AgentsrhoA GTP-Binding Proteinrho-Associated KinasesRNA, Small InterferingThymolVimentinadvanced glycation end products (AGE)human podocytesnuclear factor-kappa B (NF-κB)RhoA/ROCK pathwayThymol

Identifiers

PMID32028827
PMCPMC7757830
OpenAlexW3004569615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.