ArticleDiagnostics (Basel, Switzerland)2020
Does Endometriosis Influence the Embryo Quality and/or Development? Insights from a Large Retrospective Matched Cohort Study.
Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- The Impact of Endometriosis on Embryo Quality inFrontiers in medicine · 2021Pooled it
- In Vivo Shadows and In Vitro Light: The Early Embryological Journey Amid Endometriosis.Biology · 2025Review
- The Effects of Endometriosis on Oocyte and Embryo Quality.Journal of clinical medicine · 2025Review
- Comparison of success rates in early stages of in vitro fertilization (IVF) in women with and without endometriosis.Narra J · 2024Article
- Article
- Endometriosis and In Vitro Fertilization.Medicina (Kaunas, Lithuania) · 2024Review
- Loss of KLF15 impairs endometrial receptivity by inhibiting EMT in endometriosis.The Journal of endocrinology · 2024Article
- The Impact of Endometriosis on Reproductive Outcomes in ART Cycles.Advanced biomedical research · 2024Article
- Endometriosis and IVF treatment outcomes: unpacking the process.Reproductive biology and endocrinology : RB&E · 2023Review
- Effects of dysregulated glucose metabolism on the occurrence and ART outcome of endometriosis.European journal of medical research · 2023Article
- Morphokinetic analysis of early human embryonic development and its relationship to endometriosis resection: a retrospective time-lapse study using the KIDScore™ D3 and D5 implantation data algorithm.Archives of gynecology and obstetrics · 2023Article
- Endometriosis, Oocyte, and Embryo Quality.Journal of clinical medicine · 2023Review
- Ovarian endometrioma increases the embryo aneuploid rate: an analysis of 7092 biopsied blastocysts from fertile monogenetic disease carriers.BMC women's health · 2023Article
- Oviductal extracellular vesicles from women with endometriosis impair embryo development.Frontiers in endocrinology · 2023Article
- Higher miscarriage rate in subfertile women with endometriosis receiving unbiopsied frozen-warmed single blastocyst transfers.Frontiers in cell and developmental biology · 2023Article
- Effectiveness of gonadotrophin-releasing hormone agonist therapy to improve the outcomes of intrauterine insemination in patients suffering from stage I-II endometriosis.Annals of medicine · 2022Article
- The impact of endometriosis on embryo morphokinetics: embryos from endometriosis patients exhibit delayed cell cycle milestones and decreased blastulation rates.Journal of assisted reproduction and genetics · 2022Article
- Is Oocyte Quality Impaired in Cases With Ovarian Endometriosis? A Second Look Into the Clinical Setting.Frontiers in endocrinology · 2022Article
- Novel diagnostic options for endometriosis - Based on the glycome and microbiome.Journal of advanced research · 2021Review
- Impact of endometriosis on oocyte morphology in IVF-ICSI: retrospective study of a cohort of more than 6000 mature oocytes.Reproductive biology and endocrinology : RB&E · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vitro fertilization can be an effective tool to manage the endometriosis-associated infertility, which accounts for 10% of the strategy indications. Nevertheless, a negative effect of endometriosis on IVF outcomes has been suggested. The aim of this study was to evaluate the potential effect of endometriosis in the development of embryos at cleavege stage in assisted reproduction treatment cycles. A total of 429 cycles from women previously operated for moderate/severe endometriosis were compared with 851 cycles from non-affected women. Patients were matched by age, number of oocyte retrieved and study period. A total of 3818 embryos in cleavage stage have been analyzed retrospectively. Overall, no difference was found between women with and without endometriosis regarding the number of cleavage stage embryos obtained as well as the percentage of good/fair quality embryos. Excluding cycles in which no transfers were performed or where embryos were frozen in day three, no difference was observed for blastulation rate or the percentage of good/fair blastocysts obtained. Despite similar fertilization rate and number/quality of embryos, a reduction in ongoing pregnancy rate was observed in patients affected, possibly due to an altered endometrial receptivity or to the limited value of the conventional morphological evaluation of the embryo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.