Evidence map›Paper›PMID 32028618›Full record

ArticleGenes2020

A Missense Variant Affecting the C-Terminal Tail of UNC93B1 in Dogs with Exfoliative Cutaneous Lupus Erythematosus (ECLE).

Tosso Leeb, Fabienne Leuthard, Vidhya Jagannathan, Sarah Kiener, Anna Letko, Petra Roosje, Monika M Welle, Katherine L Gailbreath, Andrea Cannon, Monika Linek and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  7. Genes · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 3 countries.

Tosso LeebInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
Fabienne LeuthardInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
Vidhya JagannathanInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
Sarah KienerInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
Anna LetkoInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
Petra RoosjeDermfocus, University of Bern, 3001 Bern, Switzerland.
Monika M WelleDermfocus, University of Bern, 3001 Bern, Switzerland.
Katherine L GailbreathZNLabs Veterinary Diagnostics, Garden City, ID 83714, USA.
Andrea CannonWestvet, Garden City, ID 83714, USA.
Monika LinekAniCura Tierärztliche Spezialisten, 22043 Hamburg, Germany.
Frane BanovicDepartment of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Thierry OlivryDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
Stephen D WhiteDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.
Kevin BatcherDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Danika BannaschDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Katie M MinorDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN 55108, USA.
James R MickelsonDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN 55108, USA.
Marjo K HytönenDepartment of Veterinary Biosciences, University of Helsinki, 00014 Helsinki, Finland.
Hannes LohiDepartment of Veterinary Biosciences, University of Helsinki, 00014 Helsinki, Finland.
Elizabeth A MauldinUniversity of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA 19104, USA.
Margret L CasalUniversity of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA 19104, USA.
University of Bern · CHUniversity of California, Davis · USUniversity of Helsinki · FIUniversity of Minnesota · USUniversity of Pennsylvania · USNorth Carolina State University · USUniversity of Georgia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous lupus erythematosus (CLE) in humans encompasses multiple subtypes that exhibit a wide array of skin lesions and, in some cases, are associated with the development of systemic lupus erythematosus (SLE). We investigated dogs with exfoliative cutaneous lupus erythematosus (ECLE), a dog-specific form of chronic CLE that is inherited as a monogenic autosomal recessive trait. A genome-wide association study (GWAS) with 14 cases and 29 controls confirmed a previously published result that the causative variant maps to chromosome 18. Autozygosity mapping refined the ECLE locus to a 493 kb critical interval. Filtering of whole genome sequence data from two cases against 654 controls revealed a single private protein-changing variant in this critical interval,

Indexed as

Mutation, MissenseAnimalsDog DiseasesDogsGenome-Wide Association StudyLupus Erythematosus, CutaneousMaleMembrane Transport ProteinsWhole Genome SequencingMembrane Transport Proteinsanimal modelCanis familiarisCLEdermatologyimmunologyskinSLEsyndecan binding proteinsyntenin-1systemic lupus erythematosusTLR7toll-like receptor

Identifiers

PMID32028618
PMCPMC7074252
OpenAlexW3003753826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.