Evidence map›Paper›PMID 32028593›Full record

ArticleVaccines2020

Seroprevalence to Measles Virus after Vaccination or Natural Infection in an Adult Population, in Italy.

Gabriele Anichini, Claudia Gandolfo, Simonetta Fabrizi, Giovan Battista Miceli, Chiara Terrosi, Gianni Gori Savellini, Shibily Prathyumnan, Daniela Orsi, Giuseppe Battista, Maria Grazia Cusi

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 55 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Cross-sectional seroprevalence study of measles antibodies among children to identify gaps in population immunity, Ireland, 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  6. Article
  7. Article
  8. A Case Series of Adult Measles from a Tertiary Care Hospital in North India.The American journal of tropical medicine and hygiene · 2025
    Article
  9. Article
  10. Observational
  11. Review
  12. Epidemiologic and clinical updates on viral infections in Saudi Arabia.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  13. Increase in measles cases in a City hospital, Istanbul, Turkey.Central European journal of public health · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Gabriele AnichiniDepartment of Medical Biotechnologies, University of Siena, Santa Maria delle Scotte Hospital, V.le Bracci, 1 53100 Siena, Italy.ORCID 0000-0001-9895-2488
Claudia GandolfoDepartment of Medical Biotechnologies, University of Siena, Santa Maria delle Scotte Hospital, V.le Bracci, 1 53100 Siena, Italy.
Simonetta FabriziPreventive Medicine and Health Surveillance Unit, Santa Maria delle Scotte Hospital, V.le Bracci, 1 53100 Siena, Italy.
Giovan Battista MiceliPreventive Medicine and Health Surveillance Unit, Santa Maria delle Scotte Hospital, V.le Bracci, 1 53100 Siena, Italy.
Chiara TerrosiDepartment of Medical Biotechnologies, University of Siena, Santa Maria delle Scotte Hospital, V.le Bracci, 1 53100 Siena, Italy.
Gianni Gori SavelliniDepartment of Medical Biotechnologies, University of Siena, Santa Maria delle Scotte Hospital, V.le Bracci, 1 53100 Siena, Italy.ORCID 0000-0003-2287-9258
Shibily PrathyumnanDepartment of Medical Biotechnologies, University of Siena, Santa Maria delle Scotte Hospital, V.le Bracci, 1 53100 Siena, Italy.
Daniela OrsiPreventive Medicine and Health Surveillance Unit, Santa Maria delle Scotte Hospital, V.le Bracci, 1 53100 Siena, Italy.
Giuseppe BattistaPreventive Medicine and Health Surveillance Unit, Santa Maria delle Scotte Hospital, V.le Bracci, 1 53100 Siena, Italy.
Maria Grazia CusiPreventive Medicine and Health Surveillance Unit, Santa Maria delle Scotte Hospital, V.le Bracci, 1 53100 Siena, Italy.ORCID 0000-0001-8869-8164
Ospedale Santa Maria alle Scotte · ITUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An increase in measles cases worldwide, with outbreaks, has been registered in the last few years, despite the availability of a safe and highly efficacious vaccine. In addition to an inadequate vaccination coverage, even in high-income European countries studies proved that some vaccinated people were also found seronegative years after vaccination, thus increasing the number of people susceptible to measles infection. In this study, we evaluated the immunization status and the seroprevalence of measles antibodies among 1092 healthy adults, either vaccinated or naturally infected, in order to investigate the persistence of anti-measles IgG. Among subjects who received two doses of measles vaccine, the neutralizing antibody titer tended to decline over time. In addition, data collected from a neutralization assay performed on 110 healthy vaccinated subjects suggested an inverse correlation between neutralizing antibody titers and the time elapsed between the two vaccinations, with a significant decline in the neutralizing titer when the interval between the two doses was ≥11 years. On the basis of these results, monitoring the serological status of the population 10-12 years after vaccination could be important both to limit the number of people who are potentially susceptible to measles, despite the high efficacy of MMR vaccine, and to recommend a booster vaccine for the seronegatives.

Indexed as

measles virusneutralizing antibodiesseroprevalencevaccine

Identifiers

PMID32028593
PMCPMC7158681
OpenAlexW3003462054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.