ArticleMedicine2020
Saliva cortisol, melatonin levels and circadian rhythm alterations in Chinese primary school children with dyslexia.
Article in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Detailed Review of Melatonin and its Role in Managing the Symptoms of Depression.Current molecular medicine · 2026Review
- Investigating the causal relationship between insomnia and ovarian cancer risk: a Mendelian randomization study.Discover oncology · 2025Article
- A Community Study on Sleep Characteristics and Anxiety Symptoms in Children with Dyslexia.Brain sciences · 2025Article
- Stress, resilience, and emotional well-being in children and adolescents with specific learning disabilities.Current opinion in behavioral sciences · 2024Article
- Early life stress, literacy and dyslexia: an evolutionary perspective.Brain structure & function · 2024Review
- Protective effects and mechanisms of the Erzhi formula on glucocorticoid induced primary cortical neuron injury.Frontiers in pharmacology · 2023Article
- A Cross-Sectional Study of Myopia and Morning Melatonin Status in Northern Irish Adolescent Children.Journal of ophthalmology · 2023Article
- Circadian Disruption and Occupational Toxicants Exposure Affecting the Immunity of Shift Workers During SARS CoV-2 Pandemic.Frontiers in public health · 2022Review
- iTRAQ-based quantitative proteomics analysis of the hepatoprotective effect of melatonin on ANIT-induced cholestasis in rats.Experimental and therapeutic medicine · 2021Article
- Stress in the onset and aggravation of learning disabilities.Developmental review : DR · 2021Article
- Developmental Dyslexia: Environment Matters.Brain sciences · 2021Article
- Cortisol on Circadian Rhythm and Its Effect on Cardiovascular System.International journal of environmental research and public health · 2021Review
- Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease.Frontiers in genetics · 2021Review
- Recent advances in modulators of circadian rhythms: an update and perspective.Journal of enzyme inhibition and medicinal chemistry · 2020Review
- Personality, Behavior Characteristics, and Life Quality Impact of Children with Dyslexia.International journal of environmental research and public health · 2020Article
- An Evolutionary Perspective of Dyslexia, Stress, and Brain Network Homeostasis.Frontiers in human neuroscience · 2020Review
- Effect of night-shift work on cortisol circadian rhythm and melatonin levels.Sleep science (Sao Paulo, Brazil)Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortisol is the main end product of hypothalamic-pituitary-adrenal gland (HPA axis), and melatonin (MT) has a regulating effect on HPA axis, and both are closely related to individual behavior and cognitive function. We aimed to evaluate cortisol and MT roles on children dyslexia in this study.A total of 72 dyslexic children and 72 controls were recruited in this study. Saliva samples were collected in the morning, afternoon, and night, respectively. The levels of saliva cortisol and MT were measured by enzyme-linked immunosorbent assay method. Differences of cortisol and MT levels between dyslexic and normal children were compared, and the variation trend was also analyzed by dynamic monitoring in 3 time points.The levels of salivary cortisol and MT in children with dyslexia were all lower than those in normal children whether in the morning (7:30-8:30 AM ), at afternoon (15:30-16:30 PM ) or at night (21:30-22:30 PM ) (all P < .001). Compared with normal children, the circadian rhythm variations of salivary cortisol and MT in dyslexic children disappeared and became disordered. The salivary cortisol and MT levels in children with dyslexia were declined throughout the day; and the circadian rhythm was disordered or disappeared.The results suggest that cortisol and MT levels and their circadian rhythm may affect children dyslexia, but the mechanisms need further exploration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.