ArticleSleep medicine2020
Cardiovascular consequences of obstructive sleep apnea in women: a historical cohort study.
Article in Sleep medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The effect of obstructive sleep apnea on the increased risk of cardiovascular disease: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Article
- Midlife Sleep and Circadian Health: Implications for Cardiovascular and Cognitive Outcomes.Obstetrics and gynecology clinics of North America · 2026Review
- Article
- Sleep Duration and Mortality in Women: Effect of Aging and Menopause.Sleep medicine clinics · 2026Review
- Advances in the Diagnosis and Treatment of Obstructive Sleep Apnea in Women.Pulmonary therapy · 2026Review
- Effects of Auto-Titrating Mandibular Advancement Device on Autonomic Nervous System in Obstructive Sleep Apnea.Journal of personalized medicine · 2024Article
- Disparities in polysomnography referral in a high-risk cardiac population.Sleep & breathing = Schlaf & Atmung · 2024Article
- Measures of overnight oxygen saturation to characterize sleep apnea severity and predict postoperative respiratory depression.Biomedical engineering online · 2024Article
- Sex differences in cardiac transcriptomic response to neonatal sleep apnea.Physiological reports · 2024Article
- Obstructive Sleep Apnea: The Effect of Bariatric Surgery After Five Years-A Prospective Multicenter Trial.Obesity surgery · 2024Article
- A Review of Novel Oximetry Parameters for the Prediction of Cardiovascular Disease in Obstructive Sleep Apnoea.Diagnostics (Basel, Switzerland) · 2023Review
- Clinical phenotypes of obstructive sleep apnea: a cluster analysis based on sleep perception and sleep quality.Sleep & breathing = Schlaf & Atmung · 2023Article
- The forearm vascular response to sympathetic activation is attenuated in female, but not male, participants following acute intermittent hypoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Prognostic importance of obstructive sleep apnea and CPAP treatment for cardiovascular and mortality outcomes in patients with resistant hypertension: a prospective cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- High night-to-night variability in sleep apnea severity is associated with uncontrolled hypertension.NPJ digital medicine · 2023Article
- Sex-specific associations between daytime sleepiness, chronic diseases and mortality in obstructive sleep apnea.Frontiers in neuroscience · 2023Article
- Article
- Rapid eye movement sleep apnea and carotid intima thickness in men and women: a SHE-MUSTACHE cohort study.Journal of sleep research · 2022Article
- Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
OBJECTIVE/
backgroundEvidence on sex differences in the association between obstructive sleep apnea (OSA) and cardiovascular outcomes is limited and controversial. We conducted a historical cohort study to investigate this relationship. PATIENTS/
methodsClinical data on adults who underwent sleep study at a large urban academic hospital (Toronto, Canada) between 1994 and 2010 were linked to provincial health administrative data from 1991 to 2015. We fit Cox regressions to investigate the association between OSA severity and a cardiovascular composite outcome (all-cause mortality or hospitalization due to myocardial infarction, stroke, heart failure or atrial fibrillation), controlling for risk factors and stratifying by sex.
resultsA total of 10,149 subjects were included: median age of 49 years, 38% women. Over a median of 9.3 years, 1782 (18%) participants developed an outcome. The association between percentage of sleep time spent with oxygen saturation <90% and outcome was stronger for women (HR for IQR, 3 vs 0% = 1.30, 1.19-1.42) than for men (HR for IQR = 1.13, 1.06-1.21) (p for interaction = 0.01) in the adjusted model. Stratifying by sex, oxygen desaturations and heart rate in sleep were significant predictors in both men and women, while presence of daytime sleepiness, sleep efficiency and periodic leg movements in sleep were predictive in women but not in men.
conclusionsIn a large clinical cohort with suspected OSA, the impact of OSA as measured by the degree of nocturnal oxygen desaturation on the composite outcome was found to be greater in women than in men. We also found a different predictive ability of OSA-related factors by sex.
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