Evidence map›Paper›PMID 32027828›Full record

ArticleNeuron2020

Vasomotion Drives Periarterial Drainage of Aβ from the Brain.

Roxana O Carare, Roxana Aldea, Diederik Bulters, Aiman Alzetani, Anthony A Birch, Giles Richardson, Roy O Weller

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. The glymphatic hypothesis: the theory and the evidence.Fluids and barriers of the CNS · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Roxana O CarareUniversity of Southampton, Southampton, UK. Electronic address: rcn@soton.ac.uk.
Roxana AldeaUniversity of Southampton, Southampton, UK; Roche Pharma Research and Early Development (pRED), Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland.
Diederik BultersSouthampton University Hospital Trust, Southampton, UK.
Aiman AlzetaniSouthampton University Hospital Trust, Southampton, UK.
Anthony A BirchSouthampton University Hospital Trust, Southampton, UK.
Giles RichardsonUniversity of Southampton, Southampton, UK.
Roy O WellerUniversity of Southampton, Southampton, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this issue of Neuron, van Veluw et al. (2020) show that elimination of solutes from the brain along arterial walls is driven by low-frequency arteriolar oscillations and suggest that age-related reduction of this vasomotion may contribute to impaired clearance of Aβ.

Indexed as

BrainWakefulnessAnimalsArteriolesDrainageMice

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.