ArticlePloS one2020
Characterization of glucose uptake metabolism in visceral fat by 18 F-FDG PET/CT reflects inflammatory status in metabolic syndrome.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Subcutaneous Adipose Tissue FDG Uptake is Associated with Systemic Inflammatory Indices Independent of Primary-Tumor Metabolic Burden in Breast Cancer.Molecular imaging and biology · 2026Article
- Enhancing metabolic syndrome prediction using fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography data and machine learning: a comprehensive analysis.Quantitative imaging in medicine and surgery · 2025Article
- Multiorgan Imaging for Interorgan Crosstalk in Cardiometabolic Diseases.Circulation research · 2025Review
- Association between Visceral Adipose Tissue Metabolism and Cerebral Glucose Metabolism in Patients with Cognitive Impairment.International journal of molecular sciences · 2024Article
- Heart Uptake of [Pharmaceuticals (Basel, Switzerland) · 2022Article
- Evaluation of [Molecular imaging and biology · 2022Article
- An atlas of glucose uptake across the entire human body as measured by the total-body PET/CT scanner: a pilot study.Life metabolism · 2022Article
- Fluorine-18 fluorodeoxyglucose PET/CT is a suitable instrument to show the effects of lipid metabolism disorders on metabolic networks in the living organism.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Association between Visceral Adipose Tissue Metabolism and Alzheimer's Disease Pathology.Metabolites · 2022Article
- Evidence of a Gastro-Duodenal Effect on Adipose Tissue and Brain Metabolism, Potentially Mediated by Gut-Liver Inflammation: A Study with Positron Emission Tomography and OralInternational journal of molecular sciences · 2022Article
- Article
- Differences among [Scientific reports · 2021Article
- Association of Inflammatory Metabolic Activity of Psoas Muscle and Acute Myocardial Infarction: A Preliminary Observational Study withDiagnostics (Basel, Switzerland) · 2021Article
- Association of glucose uptake of visceral fat and acute myocardial infarction: a pilotCardiovascular diabetology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe inflammatory activity of visceral adipose tissue (VAT) is elevated in metabolic syndrome (MS), and associated with vulnerability to atherosclerosis. Inflammation can be assessed by glucose uptake in atherosclerotic plaques. We investigated whether the glucose uptake of VAT, assessed by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), is associated with systemic inflammatory status, and related to the number of MS components.
methods18F-FDG PET/CT was performed in a total of 203 participants: 59 without MS component; M(0), 92 with one or two MS components; M(1-2), and 52 with MS. Glucose uptake in VAT was evaluated using the mean standardized uptake value (SUVmean) and the maximum SUV (SUVmax). Glucose uptakes of immune-related organs such as the spleen and bone marrow (BM) were evaluated using the SUVmax.
resultsVAT SUVmax correlated with high-sensitivity C-reactive protein (hsCRP) and the SUVmax of spleen and BM, which reflect the status of systemic inflammation. Both hsCRP and the SUVmax of the spleen and BM were higher in the MS group than in the M(1-2) or M(0) groups. In VAT, SUVmax increased with increasing number of MS components, while SUVmean decreased.
conclusionsThe SUVmax and SUVmean of VAT assessed by 18F-FDG PET/CT reflected inflammation-driven unique glucose metabolism in the VAT of MS patients, distinct from that of atherosclerotic plaques.
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