Trial reportPloS one2020
Age effect on gray matter volume changes after sleep restriction.
Trial report in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Repeated caffeine intake suppresses cerebral grey matter responses to chronic sleep restriction in an AScientific reports · 2024Trial
- Sleep and Subjective Age: A Narrative Review of Epidemiological Evidence, Underlying Mechanisms, and Population Differences.Nature and science of sleep · 2026Review
- Article
- The enhancement of nodal properties in the dorsal visual pathway is associated with compensatory mechanisms of visuospatial cognitive abilities following total sleep deprivation.Frontiers in neuroscience · 2025Article
- Distinct effect of partial sleep deprivation associated with gray matter changes in young and old adults.Frontiers in aging neuroscience · 2025Article
- Hemispheric asymmetry in high-energy phosphate consumption during sleep-deprivation is balanced by creatine.Frontiers in neuroscience · 2025Article
- Structural alterations of the salience network in patients with insular glioma.Brain and behavior · 2023Article
- Total Sleep Deprivation Increases Brain Age Prediction Reversibly in Multisite Samples of Young Healthy Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Altered Hypothalamic Functional Connectivity Following Total Sleep Deprivation in Young Adult Males.Frontiers in neuroscience · 2021Article
- Cortical Thinning and Abnormal Structural Covariance Network After Three Hours Sleep Restriction.Frontiers in psychiatry · 2021Article
- Exercise and Fitness Neuroprotective Effects: Molecular, Brain Volume and Psychological Correlates and Their Mediating Role in Healthy Late-Middle-Aged Women and Men.Frontiers in aging neuroscience · 2021Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep deprivation disrupted functional and structural brain areas which are associated with cognition and emotion in healthy participants. However, the effect of age on the structural changes after sleep restriction remains unclear. In the current study, gray matter volume was calculated in 43 young adults and 37 old adults before and after sleep restriction. Two-way mixed analysis of variance (between-subject factor: deprivation; within-subject factor: age) was then employed to investigate differences in gray matter volume changes between young and old adults. Gaussian random field theory was applied for multiple comparison correction. Results revealed that sleep restriction decreases gray matter volume in the right thalamus, left precuneus, and postcentral gyrus. More importantly, we found a significant deprivation × age interaction effect mainly in the right dorsal/ventral anterior insula where the gray matter volume increased in young adults after sleep restriction but showed no difference in old adults. These findings highlight the crucial role of the anterior insula in the neural mechanisms underlying sleep lose, especially among young adults. The current work provided structural evidence for describing emotional dysfunction and suggests the potential effect of age on functional and structural changes after sleep restriction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.