Evidence map›Paper›PMID 32027397›Full record

ArticleAnnals of the New York Academy of Sciences2020

Delayed midazolam dose effects against soman in male and female plasma carboxylesterase knockout mice.

Erica Kundrick, Brenda Marrero-Rosado, Michael Stone, Caroline Schultz, Katie Walker, Robyn B Lee-Stubbs, Marcio de Araujo Furtado, Lucille A Lumley

Open access · greenAbstract read
In one paragraph

Article in Annals of the New York Academy of Sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Erica KundrickUS Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.
Brenda Marrero-RosadoUS Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.
Michael StoneUS Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.
Caroline SchultzUS Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.
Katie WalkerUS Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.
Robyn B Lee-StubbsUS Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.
Marcio de Araujo FurtadoUniformed Services University of Health Sciences, Bethesda, Maryland.
Lucille A LumleyUS Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.
DEVCOM Army Research Laboratory · USUniformed Services University of the Health Sciences · US

Funding

The carboxylesterase knockout mouse as a model to evaluate the efficacy of delayed medical countermeasures against soman exposureR21NS103820 · NINDS · GENEVA FOUNDATION · PI LANGE, LUCILLE · 2017 to 2018
$329k
NINDS NIH HHS R21 NS103820
6 · The paper itself

Abstract

Chemical warfare nerve agent exposure leads to status epilepticus that may progress to epileptogenesis and severe brain pathology when benzodiazepine treatment is delayed. We evaluated the dose-response effects of delayed midazolam (MDZ) on toxicity induced by soman (GD) in the plasma carboxylesterase knockout (Es1

Indexed as

Sex CharacteristicsStatus EpilepticusAnimalsCarboxylesteraseDose-Response Relationship, DrugFemaleMaleMiceMice, KnockoutMidazolamNerve AgentsSomanCarboxylesteraseCes1c protein, mouseMidazolamNerve AgentsSomancarboxylesterase knockout mousechemical warfare nerve agentepileptogenesismidazolamrefractory status epilepticus

Identifiers

PMID32027397
PMCPMC8238450
OpenAlexW3005152784

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.