Trial reportJournal of neurotrauma2020
Patient Outcomes at Twelve Months after Early Decompressive Craniectomy for Diffuse Traumatic Brain Injury in the Randomized DECRA Clinical Trial.
Trial report in Journal of neurotrauma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Surgical intervention in traumatic brain injury: a systematic review and meta-analysis of decompressive craniotomy.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Pooled it
- Guidelines for the Management of Severe Traumatic Brain Injury: 2020 Update of the Decompressive Craniectomy Recommendations.Neurosurgery · 2020Guideline
- Trial
- Decompressive Craniectomy for Intracranial Pathologies in the Intensive Care Unit : Effects on Mortality and Clinical Course.Journal of Korean Neurosurgical Society · 2026Article
- Future Directions and Evolution Strategies for the Clinical Management of Traumatic Brain Injury.Journal of clinical medicine · 2026Article
- Timing of decompressive craniectomy and short-term outcomes in pediatric severe traumatic brain injury: a nationwide observational study in Germany.Scientific reports · 2026Observational
- Current status and influencing factors of decision conflict among surrogate decision-makers for patients with severe traumatic brain injury in the ICU.Frontiers in medicine · 2026Article
- A systematic review of mortality and long-term functional outcomes after decompressive craniectomy for acquired brain injury: The missing rehabilitation reporting.AIMS neuroscience · 2026Review
- The family wants everything done: a reasonable justification for futile surgery? Illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Optic nerve sheath diameter and Pcv-aCOBMJ open · 2025Article
- Integrative Diagnostic and Prognostic Paradigms in Diffuse Axonal Injury: Insights from Clinical, Histopathological, Biomolecular, Radiological, and AI-Based Perspectives.International journal of molecular sciences · 2025Review
- Evolution from Decompressive Craniectomy to Early Minimally Invasive Surgical Approach for Refractory Increased Intracranial Pressure Treatment: Merit or Social Problems?Turkish journal of anaesthesiology and reanimation · 2025Article
- Too severe to save? Association between the timing of decompressive craniectomy and mortality in pediatric traumatic brain injury using the German hospital database.Critical care (London, England) · 2025Article
- Veterans Traumatic Brain Injuries and Neurosurgical Challenges: A Narrative Review.Health science reports · 2025Article
- Spinal cord swelling and intradural compression predict neurological recovery after acute cervical traumatic spinal cord injury.PloS one · 2025Article
- PaCONeurocritical care · 2024Article
- Review
- Effect of pain nursing intervention on patients with craniocerebral trauma combined with ocular trauma after decompressive craniectomy.Pakistan journal of medical sciences · 2024Article
- Single-centre real-life observational study on mortality and outcomes: decompressive craniectomy and brain death in traumatic brain injury, haemorrhage, and other cerebral diseases.Acta neurochirurgica · 2024Observational
- Non-pharmacological interventions for traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 9 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional outcomes at 12 months were a secondary outcome of the randomized DECRA trial of early decompressive craniectomy for severe diffuse traumatic brain injury (TBI) and refractory intracranial hypertension. In the DECRA trial, patients were randomly allocated 1:1 to either early decompressive craniectomy or intensive medical therapies (standard care). We conducted planned secondary analyses of the DECRA trial outcomes at 6 and 12 months, including all 155 patients. We measured functional outcome using the Glasgow Outcome Scale-Extended (GOS-E). We used ordered logistic regression, and dichotomized the GOS-E using logistic regression, to assess outcomes in patients overall and in survivors. We adjusted analyses for injury severity using the International Mission for Prognosis and Analysis of Clinical Trials in TBI (IMPACT) model. At 12 months, the odds ratio (OR) for worse functional outcomes in the craniectomy group (OR 1.68; 95% confidence interval [CI]: 0.96-2.93;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.