Evidence map›Paper›PMID 32027110›Full record

ArticleACS chemical neuroscience2020

Discovery and Optimization of Triazine Nitrile Inhibitors of

Jeffery D Zwicker, David Smith, Alfredo J Guerra, Jacob R Hitchens, Nicole Haug, Steve Vander Roest, Pil Lee, Bo Wen, Duxin Sun, Lu Wang and 4 more

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Legacy 4(1ACS infectious diseases · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. An update on the discovery and development of reversible covalent inhibitors.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2023
    Review
  7. Review
  8. Parasitology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Jeffery D ZwickerVahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
David SmithDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Alfredo J GuerraDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Jacob R HitchensVahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
Nicole HaugDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Steve Vander RoestCenter for Chemical Genomics, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Pil LeeVahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
Bo WenPharmacokinetics Core, Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
Duxin SunPharmacokinetics Core, Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
Lu WangPharmacokinetics Core, Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
Richard F KeepDepartment of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109, United States.
Jianming XiangDepartment of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109, United States.
Vern B CarruthersDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Scott D LarsenVahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-8440-4990
University of Michigan · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
INTERDEPARTMENTAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM007767 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 1985 to 2019
$10.2M
Rational design of CNS-permeable cathepsin L inhibitors for treatment of chronic toxoplasmosisR33AI127492 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE, WHITE, ANDREW DAVID · 2019 to 2021
$1.3M
Rational design of CNS-permeable cathepsin L inhibitors for treatment of chronic toxoplasmosisR21AI127492 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE, LARSEN, SCOTT D · 2017 to 2018
$422k
NCI NIH HHS P30 CA046592NIAID NIH HHS R21 AI127492NIAID NIH HHS R33 AI127492NIGMS NIH HHS T32 GM007767
6 · The paper itself

Abstract

With roughly 2 billion people infected, the neurotropic protozoan

Indexed as

ToxoplasmaToxoplasmosisAnimalsCathepsin LCentral Nervous SystemHumansMiceNitrilesProtozoan ProteinsTriazinesCathepsin LNitrilesProtozoan ProteinsTriazinesantiparasiticsantiprotazoal agentsblood-brain barriercathepsin Lcentral nervous systeminfectious diseaseproteaseToxoplasma gondiitoxoplasmosistriazine nitrile

Identifiers

PMID32027110
PMCPMC7431380
OpenAlexW3004578208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.