ArticleHuman brain mapping2020
Structural optimality and neurogenetic expression mediate functional dynamics in the human brain.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Enhancing Omics Analyses Through Coalitional Games and Shapley Values.Methods and protocols · 2026Article
- Internal control of brain networks via sparse feedback.AIChE journal. American Institute of Chemical Engineers · 2023Article
- Trade-offs among cost, integration, and segregation in the human connectome.Network neuroscience (Cambridge, Mass.) · 2023Article
- A Precuneal Causal Loop Mediates External and Internal Information Integration in the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Combining network topology and information theory to construct representative brain networks.Network neuroscience (Cambridge, Mass.) · 2021Article
- Structural optimality and neurogenetic expression mediate functional dynamics in the human brain.Human brain mapping · 2020Article
- Network communication models improve the behavioral and functional predictive utility of the human structural connectome.Network neuroscience (Cambridge, Mass.) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 3 countries.
Funding
Abstract
The human brain exhibits a rich functional repertoire in terms of complex functional connectivity patterns during rest and tasks. However, how this is developed upon a fixed structural anatomy remains poorly understood. Here we investigated the hypothesis that resting state functional connectivity and the manner in which it changes during tasks related to a set of underlying structural connections that promote optimal communication in the brain. We used a game-theoretic model to identify such optimal connections in the structural connectome of 50 healthy individuals and subsequently used the optimal structural connections to predict resting-state functional connectivity with high accuracy. In contrast, we found that nonoptimal connections accurately predicted functional connectivity during a working memory task. We further found that this balance between optimal and nonoptimal connections between brain regions was associated with a specific gene expression linked to neurotransmission. This multimodal evidence shows for the first time that structure-function relationships in the human brain are related to how brain networks navigate information along different white matter connections as well as the brain's underlying genetic profile.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.