ArticleActa psychiatrica Scandinavica2020
Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness.
Article in Acta psychiatrica Scandinavica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Schizophrenia Polygenic Risk and Experiences of Childhood Adversity: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2022Pooled it
- Polygenic Risk for Major Depression Interacts with Parental Criticism in Predicting Adolescent Depressive Symptom Development.Journal of youth and adolescence · 2021Pooled it
- Association between the Korea-Polyenvironmental Risk Score and Clinical Outcomes in Schizophrenia Spectrum Disorders.Schizophrenia bulletin · 2026Article
- Associations Between Genetic Risk, Physical Activities, and Distressing Psychotic-like Experiences.Schizophrenia bulletin · 2026Article
- Genetic Risk, Self-Harm, and Violence in Schizophrenia: A Narrative Review of Implications for Early Identification and Intervention.Clinical neuropsychiatry · 2025Review
- Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study.Schizophrenia bulletin · 2025Article
- Associations of polygenic risk score, environmental factors, and their interactions with the risk of schizophrenia spectrum disorders.Psychological medicine · 2025Article
- Genetic Susceptibility to the Environment Moderates the Impact of Childhood Experiences on Psychotic, Depressive, and Anxiety Dimensions.Schizophrenia bulletin · 2025Article
- Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life.Schizophrenia bulletin · 2025Article
- Cognitive presentation at psychosis onset through premorbid deterioration and exposure to environmental risk factors.Psychological medicine · 2025Article
- Association of Polygenic Risk Scores for Schizophrenia with Psychosis-Proneness Indicators in the General Population: A Narrative Review.Consortium psychiatricum · 2025Review
- Latent Profiles of Childhood Maltreatment and Their Associations with Emotional Reactivity, Alexithymia, and Emotion Regulation in Chinese College Students.Psychology research and behavior management · 2025Article
- The Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population.Schizophrenia bulletin open · 2025Article
- Association of polygenic scores for depression and neuroticism with perceived stress in daily life during a long-lasting stress period.Genes, brain, and behavior · 2023Article
- Childhood maltreatment and emotion regulation in everyday life: an experience sampling study.Scientific reports · 2023Article
- Dose-dependent changes in real-life affective well-being in healthy community-based individuals with mild to moderate childhood trauma exposure.Borderline personality disorder and emotion dysregulation · 2023Article
- Gene-environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding.Personality neuroscience · 2023Article
- Evidence for increased DNA damage repair in the postmortem brain of the high stress-response group of schizophrenia.Frontiers in psychiatry · 2023Article
- Positive Affective Recovery in Daily Life as a Momentary Mechanism Across Subclinical and Clinical Stages of Mental Disorder: Experience Sampling Study.JMIR mental health · 2022Article
- Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis: findings from the multinational EU-GEI study.Epidemiology and psychiatric sciences · 2022Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo test whether polygenic risk score for schizophrenia (PRS-S) interacts with childhood adversity and daily-life stressors to influence momentary mental state domains (negative affect, positive affect, and subtle psychosis expression) and stress-sensitivity measures.
methodsThe data were retrieved from a general population twin cohort including 593 adolescents and young adults. Childhood adversity was assessed using the Childhood Trauma Questionnaire. Daily-life stressors and momentary mental state domains were measured using ecological momentary assessment. PRS-S was trained on the latest Psychiatric Genetics Consortium schizophrenia meta-analysis. The analyses were conducted using multilevel mixed-effects tobit regression models.
resultsBoth childhood adversity and daily-life stressors were associated with increased negative affect, decreased positive affect, and increased subtle psychosis expression, while PRS-S was only associated with increased positive affect. No gene-environment correlation was detected. There is novel evidence for interaction effects between PRS-S and childhood adversity to influence momentary mental states [negative affect (b = 0.07, P = 0.013), positive affect (b = -0.05, P = 0.043), and subtle psychosis expression (b = 0.11, P = 0.007)] and stress-sensitivity measures.
conclusionExposure to childhood adversities, particularly in individuals with high PRS-S, is pleiotropically associated with emotion dysregulation and psychosis proneness.
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