ArticleAnnals of Saudi medicine
Whole slide imaging compared with light microscopy for primary diagnosis in surgical neuropathology: a validation study.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Technical and Diagnostic Issues in Whole Slide Imaging Published Validation Studies.Frontiers in oncology · 2022Pooled it
- Enhancing histology education: Iranian medical students' experience with eHistoLab web-application virtual microscopy.BMC medical education · 2026Article
- Roche Digital Pathology Dx whole slide imaging system is comparable to traditional microscopy for primary diagnosis in surgical pathology.American journal of clinical pathology · 2025Article
- Digital pathology systems enabling quality patient care.Genes, chromosomes & cancer · 2023Review
- Virtual Versus Light Microscopy Usage among Students: A Systematic Review and Meta-Analytic Evidence in Medical Education.Diagnostics (Basel, Switzerland) · 2023Review
- DigiPatICS: Digital Pathology Transformation of the Catalan Health Institute Network of 8 Hospitals-Planification, Implementation, and Preliminary Results.Diagnostics (Basel, Switzerland) · 2022Article
- Integrating digital pathology into clinical practice.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Review
- Integrated digital pathology at scale: A solution for clinical diagnostics and cancer research at a large academic medical center.Journal of the American Medical Informatics Association : JAMIA · 2021Article
- Loss of fidelity in scanned digital images compared to glass slides of brain tumors resected using cavitron ultrasonic surgical aspirator.Brain pathology (Zurich, Switzerland) · 2021Article
- The histopathological diagnosis of atypical meningioma: glass slide versus whole slide imaging for grading assessment.Virchows Archiv : an international journal of pathology · 2021Article
- Contemporary Whole Slide Imaging Devices and Their Applications within the Modern Pathology Department: A Selected Hardware Review.Journal of pathology informatics · 2021Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDigital pathology practice is rapidly gaining popularity among practicing anatomic pathologists. Acceptance is higher among the newer generation of pathologists who are willing to adapt to this new diagnostic method due to the advantages offered by whole slide imaging (WSI) compared to traditional light microscopy (TLM). We performed this validation study because we plan to implement the WSI system for diagnostic services.
objectivesDetermine the feasibility of using digital pathology for diagnostic services by assessing the equivalency of WSI and TLM.
designA laboratory-based cross-sectional study.
settingCentral laboratory at a tertiary health care center. MATERIALS AND
methodsFour practicing surgical pathologists participated in this study. Each pathologist blindly reviewed 60 surgical neuropathology cases with a minimum 8-week washout-period between the two diagnostic modalities (WSI vs. TLM). Intraobserver concordance rates between WSI and TLM diagnoses as compared to the original diagnosis were calculated.
main outcome measuresOverall intraobserver concordance rates between each diagnostic method (WSI and TLM) and original diagnosis. SAMPLE SIZE: 60 in-house surgical neuropathology cases.
resultsThe overall intraobserver concordance rate between TLM and original diagnosis was 86.3% (range 76.7%-91.7%) versus 80.8% for WSI (range 68.3%-88.3%). These findings are suggestive of the superiority of TLM, but the Fleiss' Kappa statistic indicated that the two methods are equivalent, despite the low level of the K value.
conclusionWSI is not inferior to the light microscopy and is feasible for primary diagnosis in surgical neuropathology. However, to ensure the best results, only formally trained neuropathologists should handle the digital neuropathology service. LIMITATIONS: Only one diagnostic slide per case rather than the whole set of slides, sample size was relatively small, and there was an insufficient number of participating neuropathologists. CONFLICT OF INTEREST: None.
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