ArticleAnnals of Saudi medicine
Indicators of survival and prognostic factors in women treated for cervical cancer at a tertiary care center in Saudi Arabia.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Survival status of women with cervical cancer in Sub-Saharan Africa: a systematic review and meta-analysis, 2024.Frontiers in oncology · 2024Pooled it
- Prognostic Significance of Clinicopathological Factors Influencing Overall Survival and Event-Free Survival of Patients with Cervical Cancer: A Systematic Review and Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2022Pooled it
- Sociodemographic correlates of human papilloma virus (HPV) and cervical cancer knowledge among Saudi women: A nationwide assessment.Medicine · 2026Article
- Burden and predictors of cervical cancer mortality in Sub-Saharan Africa: a systematic review and meta-analysis.Infectious agents and cancer · 2026Review
- Article
- Prognostic Factors for Cervical Cancer in Asian Populations: A Scoping Review of Research From 2013 to 2023.Cureus · 2024Article
- Human papillomavirus prevalence and dynamics: Insights from a 5-year population-based study in Jeddah, Kingdom of Saudi Arabia.Saudi medical journal · 2024Article
- Predictors of Human Papillomavirus (HPV) Vaccine Acceptability Among Physicians, Their Knowledge on Cervical Cancer, and Factors Influencing Their Decision to Recommend It.Journal of multidisciplinary healthcare · 2024Article
- Survival after Diagnosis of Cervical Cancer Patients at a Tertiary Referral Hospital in Northeast Thailand.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- A scoping review on population-centered indicators for cancer care continuum.Frontiers in public health · 2022Article
- Associated predictor covariates of cervical cancer stage and impact on survival at Khartoum oncology hospital, Sudan.F1000Research · 2021Article
- Trends of cancer incidence in Qassim Region, a descriptive analysis of data from the Saudi Cancer registry 2002-2016.International journal of health sciencesArticle
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Authors and funding
2 authors.
Funding
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Abstract
backgroundInvestigating survival in cervical cancer at the local level is crucial to determine the effectiveness of overall management, as it reflects the level of care provided and awareness among the population about screening and early diagnosis.
objectivesAnalyze overall survival (OS) and disease-free survival (DFS) among patients treated for cervical cancer and to investigate clinical, management- and outcome-related independent factors associated with survival.
designA retrospective medical record review.
settingGynecology oncology unit in a tertiary care center. PATIENTS AND
methodsAll women with cervical cancer who were treated and followed up between January 1999 and December 2017. Baseline demographic and clinical data, tumor characteristics, treatment options and outcomes including recurrence were collected and analyzed as factors and predictors of survival.
main outcome measuresOS and DFS among patients treated for cervical cancer. SAMPLE SIZE: 190 patients.
resultsThe 190 patients had a mean (SD) age of 54.2 (13.1) years (median 52.0, interquartile range, 46-62), and median (IQR) follow-up time was 37.0 (12.0-69.0) months. Tumor characteristics showed FIGO stage (I [19.0%], II [48.9%], III [18.4%], IV [13.6%]), grade (I [15.8%], II [46.8%], III [35.8%]) and the most frequent histological type was squamous cell carcinoma (77.4%). Patients received initial radiotherapy with concurrent chemotherapy (53.2%), initial radical hysterectomy (24.7%), systemic chemotherapy (6.3%) and palliative care (4.7%). Mean OS and DFS were 97.1 (82.2, 111.9) and 85.2 (70.4, 100.0) months, respectively. Recurrence and mortality rates were 25.8% and 46.8%, occurring after a median (IQR) time=13.0 (6.0-28.0) and 20.0 (9.0-45.0) months, respectively. Survival was independently associated with grade II (hazard ratio [HR]=3.6, 95%CI: 1.3-9.7, P=.012), grade III (HR=4.5, 95%CI:1.6-12.6, P=.004), number of regional organs involved (1-3 organs: HR=7.8, 95%CI: 1.2, 49.1, P=.030), and recurrence (HR=2.23, P=.001).
conclusionSurvival was about 8 years in our institution, which is predicted by the tumor grade, regional organs involved and recurrence. Remarkably, this study found a high percentage of patients diagnosed at an advanced stage, which probably impacts survival and stresses the need for improving early detection. LIMITATIONS: Retrospective design, resulting in recall bias and missing data. CONFLICT OF INTEREST: None.
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