Evidence map›Paper›PMID 32026576›Full record

ArticlePhysiological reports2020

Fetal cardiovascular response to acute hypoxia during maternal anesthesia.

Tamara J Varcoe, Jack R T Darby, Stacey L Holman, Emma L Bradshaw, Tim Kuchel, Lewis Vaughan, Michael Seed, Michael D Wiese, Janna L Morrison

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Advanced imaging of fetal cardiac function.Frontiers in cardiovascular medicine · 2023
    Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Tamara J VarcoeEarly Origins of Adult Health Research Group, University of South Australia, Adelaide, Australia.
Jack R T DarbyEarly Origins of Adult Health Research Group, University of South Australia, Adelaide, Australia.ORCID 0000-0001-7114-3920
Stacey L HolmanEarly Origins of Adult Health Research Group, University of South Australia, Adelaide, Australia.ORCID 0000-0002-6326-4797
Emma L BradshawEarly Origins of Adult Health Research Group, University of South Australia, Adelaide, Australia.
Tim KuchelSouth Australian Health and Medical Research Institute, Adelaide, Australia.
Lewis VaughanSouth Australian Health and Medical Research Institute, Adelaide, Australia.
Michael SeedHospital for Sick Children, Toronto, Canada.
Michael D WieseSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.
Janna L MorrisonEarly Origins of Adult Health Research Group, University of South Australia, Adelaide, Australia.ORCID 0000-0002-8602-8519
University of South Australia · AUSouth Australian Health and Medical Research Institute · AUHospital for Sick Children · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preclinical imaging studies of fetal hemodynamics require anesthesia to immobilize the animal. This may induce cardiovascular depression and confound measures under investigation. We compared the impact of four anesthetic regimes upon maternal and fetal blood gas and hemodynamics during baseline periods of normoxia, and in response to an acute hypoxic challenge in pregnant sheep. Merino ewes were surgically prepared with maternal and fetal vascular catheters and a fetal femoral artery flow probe at 105-109 days gestation. At 110-120 days gestation, ewes were anesthetized with either isoflurane (1.6%), isoflurane (0.8%) plus ketamine (3.6 mg·kg

Indexed as

AnesthesiaAnimalsBlood PressureFemaleFetal HypoxiaHypnotics and SedativesIsofluraneKetamineMidazolamNitrogenOxygenPropofolRegional Blood FlowSheepHypnotics and SedativesIsofluraneKetamineMidazolamNitrogenOxygenPropofolacute hypoxiaanesthesiablood pressurefetus

Identifiers

PMID32026576
PMCPMC7002532
OpenAlexW3004908419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.