Evidence map›Paper›PMID 32026446›Full record

ArticleNeurocritical care2020

Outcomes of Acute Stroke Patients Requiring Mechanical Ventilation: Study Protocol for the SPICE Multicenter Prospective Observational Study.

R Sonneville, M Mazighi, D Bresson, I Crassard, S Crozier, E de Montmollin, V Degos, F Faugeras, E Gayat, L Josse and 10 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Publisher
In one paragraph

Article in Neurocritical care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03335995 (Stroke Prognosis in Intensive CarE - The SPICE Registry), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03335995 completednot on this map

Stroke Prognosis in Intensive CarE - The SPICE Registry

TypeobservationalSponsorInstitut National de la Santé Et de la Recherche Médicale, FranceRan2017 to 2020Enrolled364ConditionsAcute Stroke Patients Requiring Invasive Mechanical Ventilation
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

R Sonneville *INSERM UMR1148, Team 6, Université de Paris, 75018, Paris, France. romain.sonneville@aphp.fr.ORCID http://orcid.org/0000-0003-0245-309X
M Mazighi *INSERM UMR1148, Team 6, Université de Paris, 75018, Paris, France.
D BressonDepartment of Neurosurgery, Henri Mondor University Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
I CrassardDepartment of Neurology, Lariboisière University Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
S CrozierDepartment of Neurology, Pitié-Salpétrière University Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
E de MontmollinAPHP, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, 46 Rue Henri Huchard, 75018, Paris, France.
V DegosDepartment of Critical Care, Anesthesia and Perioperative Medicine, Pitié-Salpétrière Hospital, Assistance Publique - Hôpitaux de Paris-Sorbonne University, Paris, France.
F FaugerasDepartment of Neurology, Henri Mondor University Hospital, Assistance Publique - Hôpitaux de Paris, Créteil, France.
E GayatDepartment of Anesthesiology and Critical Care, DMU Parabol, APHP Nord, Université de Paris, Paris, France.
L JosseDepartment of Rehabilitation Medicine, Fernand Widal University Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
C LamyDepartment of Neurology, Saint Anne Hospital, Paris, France.
E MagalhaesDepartment of Intensive Care Medicine, Sud Francilien Hospital, Corbeil, France.
A MaldjianDepartment of Rehabilitation Medicine, 317 Lostihuel Braz, 56250, Sulniac, France.
S RucklyAPHP, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, 46 Rue Henri Huchard, 75018, Paris, France.
J ServanDepartment of Neurology, André Mignot Hospital, Le Chesnay, France.
P VasselDepartment of Rehabilitation Medicine, Le Parc, Pontault-Combault, France.
B ViguéDepartment of Anesthesiology and Critical Care, Kremlin Bicêtre University Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
J-F TimsitAPHP, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, 46 Rue Henri Huchard, 75018, Paris, France.
F WoimantDepartment of Neurology, Lariboisière University Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
SPICE investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCare pathways and long-term outcomes of acute stroke patients requiring mechanical ventilation have not been thoroughly studied. METHODS AND

resultsStroke Prognosis in Intensive Care (SPICE) is a prospective multicenter cohort study which will be conducted in 34 intensive care units (ICUs) in the Paris, France area. Patients will be eligible if they meet all of the following inclusion criteria: (1) age of 18 years or older; (2) acute stroke (i.e., ischemic stroke, intracranial hemorrhage, or subarachnoid hemorrhage) diagnosed on neuroimaging; (3) ICU admission within 7 days before or after stroke onset; and (4) need for mechanical ventilation for a duration of at least 24 h. Patients will be excluded if they meet any of the following: (1) stroke of traumatic origin; (2) refusal to participate; and (3) privation of liberty by administrative or judicial decision. The primary endpoint is poor functional outcome at 1 year, defined by a score of 4 to 6 on the modified Rankin scale (mRS), indicating severe disability or death. Main secondary endpoints will include decisions to withhold or withdraw care, mRS scores at 3 and 6 months, and health-related quality of life at 1 year.

conclusionsThe SPICE multicenter study will investigate 1-year outcomes, ethical issues, as well as care pathways of acute stroke patients requiring invasive ventilation in the ICU. Gathered data will delineate human resources and facilities needs for adequate management. The identification of prognostic factors at the acute phase will help to identify patients who may benefit from prolonged intensive care and rehabilitation.

trial registrationNCT03335995.

Indexed as

Functional StatusQuality of LifeRespiration, ArtificialFranceHemorrhagic StrokeHumansIntensive Care UnitsIschemic StrokeMortalityMulticenter Studies as TopicObservational Studies as TopicPrognosisStrokeSubarachnoid HemorrhageWithholding TreatmentIntensive care unitMechanical ventilationOutcomeStroke

Identifiers

PMID32026446

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.