ArticleAging clinical and experimental research2020
Differences between muscle from osteoporotic and osteoarthritic subjects: in vitro study by diffusion-tensor MRI and histological findings.
Article in Aging clinical and experimental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Feasibility of neurite oriented diffusion and density imaging in thigh skeletal muscle of volunteers with knee pain: relationship with proton density fat fraction: a cross-sectional study.BMC medical imaging · 2026Article
- The Relationship Between Magnetic Resonance Diffusion Tensor Imaging Parameters and Muscle Dysfunction in Patients with Osteoporosis: A Cross-Sectional Retrospective Study.International journal of general medicine · 2026Article
- Association between visceral adiposity index and osteoarthritis in U.S. adults aged 50 and older: a cross-sectional study.Frontiers in nutrition · 2025Article
- Modulation of Carnitine Palmitoyl Transferase 1b Expression and Activity in Muscle Pathophysiology in Osteoarthritis and Osteoporosis.Biomolecules · 2024Article
- Links among Obesity, Type 2 Diabetes Mellitus, and Osteoporosis: Bone as a Target.International journal of molecular sciences · 2024Review
- Advancements in sarcopenia diagnosis: from imaging techniques to non-radiation assessments.Frontiers in medical technology · 2024Review
- Review
- MR-Imaging in Osteoarthritis: Current Standard of Practice and Future Outlook.Diagnostics (Basel, Switzerland) · 2023Review
- Complexity and data mining in dental research: A network medicine perspective on interceptive orthodontics.Orthodontics & craniofacial research · 2021Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOsteoarthritis and osteoporosis are strongly coupled with alterations of muscles quality and fats metabolism. However, there are no studies for investigating possible differences between osteoporotic and osteoarthritic muscles. Understanding muscle-bone and muscle-cartilage interactions would be of high clinical value.
aimInvestigate potential microstructural and physiological differences between osteoporotic and osteoarthritic muscles by diffusion Nuclear Magnetic Resonance (NMR) imaging (diffusion MRI) and histological findings.
methodsVastus-lateralis muscles excised from osteoporotic (n = 26, T Score < - 2.5, Kellgren-Lawrence ≤ 2) and osteoarthritic (n = 26, T Score > - 2.5, Kellgren--Lawrence 3 and 4) age-matched women were investigated by NMR relaxometry, diffusion-tensor imaging (DTI) at 9.4 T, and histological techniques. Intramyocellular (IMCL) and extramyocellular (EMCL) lipid were quantified. The percentage and mean diameters of fibers I and II were evaluated. Relationship between mean diffusivity (MD), fractional anisotropy (FA), the DTI eigenvalues (λ
resultsOsteoporotic muscles showed higher MD, λ
conclusionThis work highlights differences between muscles of osteoporotic and osteoarthritic subjects that can be quantified by NMR DTI investigations.
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