Evidence map›Paper›PMID 32026424›Full record

ArticlePulmonary therapy2019

Epidemiology of Pulmonary Fibrosis: A Cohort Study Using Healthcare Data in Sweden.

Giovanni Ferrara, Lisen Arnheim-Dahlström, Karen Bartley, Christer Janson, Klaus-Uwe Kirchgässler, Aaron Levine, C Magnus Sköld

Open access · goldAbstract read
In one paragraph

Article in Pulmonary therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Occurrence of Idiopathic Pulmonary Fibrosis in Italy: Latest Evidence from Real-World Data.International journal of environmental research and public health · 2022
    Observational
  7. Article
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Giovanni FerraraDepartment of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.
Lisen Arnheim-DahlströmIQVIA, Solna, Sweden.
Karen BartleyGenentech, Inc., South San Francisco, CA, USA.
Christer JansonDepartment of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
Klaus-Uwe KirchgässlerF. Hoffmann-La Roche, Ltd., Basel, Switzerland.
Aaron LevineIQVIA, Solna, Sweden.
C Magnus SköldDepartment of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden. Magnus.Skold@ki.se.
Karolinska Institutet · SEKarolinska University Hospital · SERoche (Switzerland) · CHUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionData on the epidemiology of idiopathic pulmonary fibrosis (IPF) in Sweden are lacking. This study estimates the incidence and prevalence of IPF in Sweden, and describes the demographic and clinical characteristics and the overall survival of patients with IPF.

methodsTwo cohorts were studied: a national cohort of 17,247 patients with pulmonary fibrosis (ICD-10 code J84.1 with no competing diagnosis) from the Swedish National Patient Register (cohort 1 [C1]); and an electronic medical record-based regional subset of C1 comprising 1755 patients having pulmonary fibrosis and a radiology procedure (C2).

resultsThe incidence of pulmonary fibrosis in C1 ranged from 10.4 to 15.4 cases per 100,000 population per year between 2001 and 2015. The prevalence increased from 15.4 to 68.0 cases per 100,000 population per year. Patients ≥ 70 years and men had a higher incidence and prevalence of pulmonary fibrosis. Common comorbidities included respiratory infections and cardiovascular disorders. Approximately one-third of patients in each cohort were hospitalised with pulmonary fibrosis within a year of diagnosis. The median survival time from disease diagnosis was 2.6 years in C1 and 5.2 years in C2. Older patients had a higher risk of hospitalisation and mortality. Women had a better prognosis than men.

conclusionThis study underscores the importance of pulmonary fibrosis as a cause of respiratory-related morbidity and mortality in Sweden. The stable incidence and increasing prevalence over time suggests longer survival. The higher morbidity and mortality in older patients highlights the importance of early case detection, diagnosis and management for better prognosis.

fundingF. Hoffmann-La Roche, Ltd./Genentech, Inc.

Indexed as

EpidemiologyIdiopathic pulmonary fibrosisReal-world evidenceRetrospective cohortSweden

Identifiers

PMID32026424
PMCPMC6967025
OpenAlexW2919319175

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.