ArticlePulmonary therapy2019
In Vitro Study of the Effect of Breathing Pattern on Aerosol Delivery During High-Flow Nasal Therapy.
Article in Pulmonary therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Comparison of the Application of Vibrating Mesh Nebulizer and Jet Nebulizer in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis.International journal of chronic obstructive pulmonary disease · 2024Pooled it
- Vibrating Mesh Nebulizer (A-VMN) Performance During Low-Flow Nasal Oxygen Therapy in Neonates.Pharmaceutics · 2026Article
- Performance Characterisation of the Airvo2Pharmaceutics · 2024Article
- Evaluation of antibody drug delivery efficiency via nebulizer in various airway models and breathing patterns.BMC pharmacology & toxicology · 2023Article
- In-Line Aerosol Therapy via Nasal Cannula during Adult and Paediatric Normal, Obstructive, and Restrictive Breathing.Pharmaceutics · 2023Article
- Enhanced Aerosol Delivery During High-Flow Nasal Cannula Therapy.Respiratory care · 2023Article
- In Vitro Model for Analysis of High-Flow Aerosol Delivery During Continuous Nebulization.Respiratory care · 2023Article
- Aerosol release, distribution, and prevention during aerosol therapy: a simulated model for infection control.Drug delivery · 2022Article
- Formulation, Device, and Clinical Factors Influencing the Targeted Delivery of COVID-19 Vaccines to the Lungs.AAPS PharmSciTech · 2022Review
- [Can mesh nebulizers improve prehospital aerosol therapy? An in vitro study on simulated prehospital emergency patients suffering from respiratory distress].Die Anaesthesiologie · 2022Article
- Evaluation of aerosol drug delivery with concurrent low- and high-flow nasal oxygen.ERJ open research · 2022Article
- The Impact of Head Model Choice on the In Vitro Evaluation of Aerosol Drug Delivery.Pharmaceutics · 2021Article
- In vitro delivery efficiencies of nebulizers for different breathing patterns.Biomedical engineering online · 2021Article
- An experimental study of respiratory aerosol transport in phantom lung bronchioles.Physics of fluids (Woodbury, N.Y. : 1994) · 2020Article
- Defining a Regulatory Strategy for ATMP/Aerosol Delivery Device Combinations in the Treatment of Respiratory Disease.Pharmaceutics · 2020Review
- CFD Guided Optimization of Nose-to-Lung Aerosol Delivery in Adults: Effects of Inhalation Waveforms and Synchronized Aerosol Delivery.Pharmaceutical research · 2020Article
- A narrative review on trans-nasal pulmonary aerosol delivery.Critical care (London, England) · 2020Review
- In vitro comparison between inspiration synchronized and continuous vibrating mesh nebulizer during trans-nasal aerosol delivery.Intensive care medicine experimental · 2020Article
- Investigation of Fugitive Aerosols Released into the Environment during High-Flow Therapy.Pharmaceutics · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe use of concurrent aerosol delivery during high-flow nasal therapy (HFNT) may be exploited to facilitate delivery of a variety of prescribed medications for inhalation. The study assessed the effect of tidal volume, breath rate, and inspiratory:expiratory (I:E) ratio on the quantity of aerosol captured at the level of the trachea during simulated HFNT.
methodsTesting was completed according to a factorial statistical design of experiments (DOE) approach. Tracheal dose was characterized with a vibrating mesh nebulizer (Aerogen Solo, Aerogen Ltd) using simulated adult, small child, and infant HFNT models. Furthermore, aerosol delivery was evaluated across a range of adult patient profiles with clinically representative test setups.
resultsAerosol delivery increased with a large tidal volume, a rapid breath rate, and a long inspiratory time. Tidal volume, breath rate, and I:E ratio each had a significant effect on tracheal dose across simulated adult, small child, and infant breathing.
conclusionThe main trends that were identified in the statistical DOE predicted aerosol delivery across adult patient breathing profiles, in terms of tidal volume, breath rate, and I:E ratio. Therefore, patients with distressed breathing profiles may be expected to receive a larger aerosol dose than those with normal breathing rates.
fundingAerogen Limited.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.