ArticlePulmonary therapy2019
Dehydroepiandrosterone Supplementation May Benefit Women with Asthma Who Have Low Androgen Levels: A Pilot Study.
Article in Pulmonary therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase IIa Clinical Trial to Evaluate Pharmacokinetics and Safety of Slow Release DHEA
A Study to Evaluate Efficacy and Safety of Slow Release DHEA
Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Trial
- Sexual Dimorphism in Allergic and Mast Cell-Associated Diseases.Clinical reviews in allergy & immunology · 2026Review
- The testosterone paradox in asthma.Frontiers in allergy · 2026Review
- Sex differences in immune cells: mechanistic perspectives and clinical correlates in physiology and disease.Frontiers in immunology · 2026Review
- Sex, hormones, and lung health.Physiological reviews · 2026Review
- Sex Differences in Asthma Pathogenesis.Immunological reviews · 2026Review
- Asthma risk: the inseparable synergy of obesity and metabolism.BMC pulmonary medicine · 2025Article
- Association between orchiectomy and asthma: Insights from 2 population-based cohorts.The journal of allergy and clinical immunology. Global · 2025Article
- Reconsidering Gender in Asthma: Is It All About Sex? A Perspective Review.Journal of clinical medicine · 2025Article
- Comprehensive sequencing of the lung neuroimmune landscape in response to asthmatic induction.Frontiers in immunology · 2025Article
- Demographic and regional analysis of 22 years of mortality data from coexisting asthma and cardiovascular disease in the United States.Proceedings (Baylor University. Medical Center) · 2025Article
- Combination of androgen and estrogen improves asthma by mediating Runx3 expression.International journal of medical sciences · 2024Article
- Sex hormones and allergies: exploring the gender differences in immune responses.Frontiers in allergy · 2024Review
- The Influence of Sex Hormones and X Chromosome in Immune Responses.Current topics in microbiology and immunology · 2023Review
- Association Between Asthma and Reduced Androgen Receptor Expression in Airways.Journal of the Endocrine Society · 2022Article
- Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation.The Journal of clinical investigation · 2022Article
- Understanding sex differences in the allergic immune response to food.AIMS allergy and immunology · 2022Article
- Sex and gender in asthma.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Benefits of Airway Androgen Receptor Expression in Human Asthma.American journal of respiratory and critical care medicine · 2021Article
- Role of Sex Hormones at Different Physiobiological Conditions and Therapeutic Potential in MBD2 Mediated Severe Asthma.Oxidative medicine and cellular longevity · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
introductionAmong individuals with severe asthma, FEV
methodsPremenopausal, nonsmoking, otherwise healthy women, 18-50 years old, with mild or moderate asthma and baseline FEV
resultsSerum DHEAS increased with DHEA treatment in women with starting DHEAS < 200 µg/dL: this increase was from 71 ± 23 to 725 ± 295 µg/dL (n = 10; p = 0.0001). The increase in the high-DHEAS group was smaller. Post-albuterol FEV
conclusionsEndocrine treatments (corticosteroids) are a mainstay of anti-inflammatory management for moderate and severe asthma. Their use has improved asthma outcomes. Androgens also reduce airway inflammation and promote airway smooth muscle relaxation, but are rarely used clinically for asthma treatment. Our results suggest that the over-the-counter steroid DHEA may improve lung function in asthma outcomes among women with DHEAS < 200 ug/dL.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.