ArticleMedical & biological engineering & computing2020
Simulation study of transcatheter heart valve implantation in patients with stenotic bicuspid aortic valve.
Article in Medical & biological engineering & computing, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- In Silico Modeling and Validation of Post-Dilation in TAVI Patients.Annals of biomedical engineering · 2026Article
- Fully coupled patient-specific fluid-structure interaction modeling of post-TAVI hemodynamics compared with echocardiographic measurements.Biomechanics and modeling in mechanobiology · 2026Article
- Mechanical Behavior of Valve Stents in Diverse Bicuspid Aortic Valves: Influence of Structural Design and Annular Eccentricity.Cardiovascular engineering and technology · 2026Article
- Evolving capabilities of computed tomography imaging for transcatheter valvular heart interventions - new opportunities for precision medicine.The international journal of cardiovascular imaging · 2026Review
- Credibility assessment of patient-specific modeling in transcatheter aortic valve implantation. I. A population-based validation of patient-specific modeling.APL bioengineering · 2025Article
- Predicting procedural outcomes in transcatheter aortic valve implantation: a scoping review of numerical patient-specific simulations.Progress in biomedical engineering (Bristol, England) · 2025Article
- Generation of a virtual cohort of TAVI patients for in silico trials: a statistical shape and machine learning analysis.Medical & biological engineering & computing · 2025Article
- Finite Element Analysis of Evolut Transcatheter Heart Valves: Effects of Aortic Geometries and Valve Sizes on Post-TAVI Wall Stresses and Deformations.Journal of clinical medicine · 2025Article
- Fluid-Solid Interaction Analysis for Developing In-Situ Strain and Flow Sensors for Prosthetic Valve Monitoring.Sensors (Basel, Switzerland) · 2024Article
- On the Material Constitutive Behavior of the Aortic Root in Patients with Transcatheter Aortic Valve Implantation.Cardiovascular engineering and technology · 2024Article
- Differences in blood flow dynamics between balloon- and self-expandable valves in patients with aortic stenosis undergoing transcatheter aortic valve replacement.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- A Systematic Review of Individualized Heart Surgery with a Personalized Prosthesis.Journal of personalized medicine · 2023Review
- Latest Developments in Adapting Deep Learning for Assessing TAVR Procedures and Outcomes.Journal of clinical medicine · 2023Review
- Transcatheter Tricuspid Valve Replacement: Illustrative Case Reports and Review of State-of-Art.Journal of clinical medicine · 2023Review
- Parametric analysis of transcatheter aortic valve replacement in transcatheter aortic valve replacement: evaluation of coronary flow obstruction.Frontiers in bioengineering and biotechnology · 2023Article
- Biomechanical performance of the Bicaval Transcatheter System for the treatment of severe tricuspid regurgitation.Frontiers in bioengineering and biotechnology · 2023Article
- Validating In Silico and In Vitro Patient-Specific Structural and Flow Models with Transcatheter Bicuspid Aortic Valve Replacement Procedure.Cardiovascular engineering and technology · 2022Article
- Virtual Reality in the Preoperative Planning of Adult Aortic Surgery: A Feasibility Study.Journal of cardiovascular development and disease · 2022Article
- Fluid-Structure Interaction Analysis on the Influence of the Aortic Valve Stent Leaflet Structure in Hemodynamics.Frontiers in physiology · 2022Article
- Potential Applications of Computational Fluid Dynamics for Predicting Hemolysis in Mitral Paravalvular Leaks.Journal of clinical medicine · 2021Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Bicuspid aortic valve (BAV) anatomy has routinely been considered an exclusion in the setting of transcatheter aortic valve implantation (TAVI) because of the large dimension of the aortic annulus having a more calcified, bulky, and irregular shape. The study aims to develop a patient-specific computational framework to virtually simulate TAVI in stenotic BAV patients using the Edwards SAPIEN 3 valve (S3) and its improved version SAPIEN 3 Ultra and quantify stent frame deformity as well as the severity of paravalvular leakage (PVL). Specifically, the aortic root anatomy of n.9 BAV patients who underwent TAVI was reconstructed from pre-operative CT imaging. Crimping and deployment of S3 frame were performed and then followed by fluid-solid interaction analysis to simulate valve leaflet dynamics throughout the entire cardiac cycle. Modeling revealed that the S3 stent frame expanded well on BAV anatomy with an elliptical shape at the aortic annulus. Comparison of predicted S3 deformity as assessed by eccentricity and expansion indices demonstrated a good agreement with the measurement obtained from CT imaging. Blood particle flow analysis demonstrated a backward blood jet during diastole, whereas the predicted PVL flows corresponded well with those determined by transesophageal echocardiography. This study represents a further step towards the use of personalized simulations to virtually plan TAVI, aiming at improving not only the efficacy of the implantation but also the exploration of "off-label" applications as the TAVI in the setting of BAV patients. Graphical abstract Computational frameworks of TAVI in patients with stenotic bicuspid aortic valve.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.