Evidence map›Paper›PMID 32025764›Full record

ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2020

Vancomycin-soaked autografts during ACL reconstruction reduce the risk of post-operative infection without affecting return to sport or knee function.

Yoann Bohu, Shahnaz Klouche, Hasan Basri Sezer, Serge Herman, Olivier Grimaud, Antoine Gerometta, Alain Meyer, Nicolas Lefevre

Erratum issued 2 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02511158 recruitingnot on this map

Prospective Follow-up Study of Patients Undergoing Knee Ligament Surgery

Typeobservational_patient_registrySponsorFonds de Dotation pour la Recherche Clinique en Orthopédie et Pathologie du SportRan2012 to 2052Enrolled7,000ConditionsRupture of Anterior Cruciate Ligament, OsteoarthritisArmsLigament of the knee reconstruction
NCT06166381 narecruitingnot on this mapstarted 2024, after this paper: background citation

Parenteral Versus Combined Parenteral With Vancomycin-soaked Graft in Decreasing the Risk of Infection in ACL Reconstruction Surgery: A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of DuhokRan2024 to 2025Enrolled288ConditionsInfection, BacterialArmsParenteral Antibacterial Agents, Parenteral Antibacterial Agents plus Vancomycin pre-soaked graft
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  14. Observational
  15. Allograft contamination during suture preparation for anterior cruciate ligament reconstruction: an ex vivo study.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022
    Article
  16. Review
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  18. Surgeon practice patterns for pre-soaking ACL tendon grafts in vancomycin: a survey of the ACL study group.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yoann BohuClinique du Sport Paris, 36 Boulevard Saint Marcel, 75005, Paris, France.
Shahnaz KloucheClinique du Sport Paris, 36 Boulevard Saint Marcel, 75005, Paris, France. klouche_shahnaz@yahoo.fr.ORCID http://orcid.org/0000-0002-9591-9831
Hasan Basri SezerClinique du Sport Paris, 36 Boulevard Saint Marcel, 75005, Paris, France.
Serge HermanClinique du Sport Paris, 36 Boulevard Saint Marcel, 75005, Paris, France.
Olivier GrimaudClinique du Sport Paris, 36 Boulevard Saint Marcel, 75005, Paris, France.
Antoine GeromettaClinique du Sport Paris, 36 Boulevard Saint Marcel, 75005, Paris, France.
Alain MeyerClinique du Sport Paris, 36 Boulevard Saint Marcel, 75005, Paris, France.
Nicolas LefevreClinique du Sport Paris, 36 Boulevard Saint Marcel, 75005, Paris, France.
Institut de France · FRYahoo (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare return to sport and knee function 1 year after anterior cruciate ligament (ACL) reconstruction using autografts with and without vancomycin presoaking.

methodsA case-control study based on a retrospective analysis of prospective data included athletes over the age of 16 operated from 2012 to 2018 for ACL reconstruction. There were two groups of patients due to a change in treatment protocols: Group 1 « without vancomycin » before November 2016 and Group 2 « with vancomycin» after this date. In Group 2, the graft was soaked in a vancomycin solution for 10 min and then fixed into the bone tunnels. The primary evaluation criterion was the return to sport 1 year after surgery. The secondary criteria were various knee scores. The number of patients needed to perform a non-inferiority study was calculated.

results1674 patients fulfilled the selection criteria, 1184 in Group 1 and 490 in Group 2. The series included 1112 men and 562 women, mean age 30 ± 9.7 years, 68 professional athletes, 674 competitive athletes and 932 recreational athletes. While seven patients presented with post-operative septic arthritis in Group 1, this complication was not found in Group 2. No significant difference was identified in the return to running between the two groups 1 year after surgery (75.9% vs. 76.1%, n.s.). Significantly more of the patients in Group 2 returned to their preinjury sport (p = 0.04). Knee function was comparable between the groups.

conclusionVancomycin-soaked grafts during ACL reconstruction reduce the risk of post-operative infection of the knee without affecting the return to sport or knee function. LEVEL OF EVIDENCE: III.

trial registrationhttps://clinicaltrials.gov/ , ClinicalTrials.gov Identifier: NCT02511158.

Indexed as

AutograftsReturn to SportAdultAnterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionAnti-Bacterial AgentsAthletic InjuriesCase-Control StudiesFemaleHumansMalePostoperative ComplicationsRetrospective StudiesRisk FactorsSurgical Wound InfectionTransplantation, AutologousAnti-Bacterial AgentsVancomycinACL reconstructionComparative studyFunctional resultsReturn to sportVancomycin

Identifiers

PMID32025764
PMCPMC7429534
OpenAlexW3004833208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.