ArticleDer Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen2020
[Diagnostic and prognostic significance of α-fetoprotein in hepatocellular carcinoma].
Article in Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Development of a novel diagnostic model integrating microRNAs and GALAD for HBV-related hepatocellular carcinoma.Biomarkers in medicine · 2025Article
- Nomograms established for predicting microvascular invasion and early recurrence in patients with small hepatocellular carcinoma.BMC cancer · 2024Article
- Early prediction of microvascular invasion (MVI) occurrence in hepatocellular carcinoma (HCC) byEuropean journal of medical research · 2024Article
- Folic/lactobionic acid dual-targeted polymeric nanocapsules for potential treatment of hepatocellular carcinoma.Drug delivery and translational research · 2024Article
- The Role of H2-Calponin Antigen in Cancer Metastasis: Presence of Autoantibodies in Liver Cancer Patients.International journal of molecular sciences · 2023Article
- Integrated profiling identifies ITGB3BP as prognostic biomarker for hepatocellular carcinoma.Bosnian journal of basic medical sciences · 2021Article
- Prognostic Value of Serum Osteoprotegerin Level in Patients With Hepatocellular Carcinoma Following Surgical Resection.Frontiers in oncology · 2021Article
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11 authors.
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Abstract
backgroundHepatocellular carcinoma (HCC) is an aggressive tumor with a growing socioeconomic burden. International guidelines do not predominantly recommend the pretherapeutic determination of the alpha-fetoprotein (AFP) concentration. Regarding the prognostic value of AFP, the European study data are not sufficiently meaningful.
objectiveThis study aimed to demonstrate possible aspects of the AFP level and to investigate the prognostic value of AFP levels as well as to provide impetus for future prospective studies. MATERIAL AND
methodsAt the time of data retrieval the prospective liver databank showed 1382 entries. All patients with a histologically confirmed HCC were included resulting in 92 final entries. For these patients, information on T, N, M and G stages, R status as well as sex, age and etiology of the HCC were available. For data analysis the patient population was divided into six groups based on three cut-off values. Furthermore, a survival analysis was performed using Kaplan-Meier and a multifactorial analysis of the influencing factors regarding outcome.
resultsThe AFP serum level showed a statistically significant correlation with the tumor diameter (T1/T2 vs. T3/T4) and grading (G1/G2 vs. G3/G4). The survival prognosis was significantly lower in patients with higher AFP values (p < 0.05). The median survival time for patients with AFP levels >8 μg/l was 35 months, with AFP levels >200 μg/l or >400 μg/l showed a reduced median survival of 15 months and 11 months, respectively. High AFP levels were a significant influencing factor for the outcome independent of the T stage, age and R status of patients in comparison to low AFP levels.
conclusionTaking the present results into consideration, the AFP level can have a therapeutic usefulness. Therapeutic consequences could be derived from the height of the measured AFP concentration, with respect to the treatment strategy. Therefore, preoperative and postoperative determination of the AFP serum level is recommended in all HCC patients.
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