Evidence map›Paper›PMID 32025650›Full record

ArticleJAMIA open2019

Using natural language processing to construct a metastatic breast cancer cohort from linked cancer registry and electronic medical records data.

Albee Y Ling, Allison W Kurian, Jennifer L Caswell-Jin, George W Sledge, Nigam H Shah, Suzanne R Tamang

Open access · goldAbstract read
In one paragraph

Article in JAMIA open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

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  17. Deploying a national clinical text processing infrastructure.Journal of the American Medical Informatics Association : JAMIA · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Albee Y LingBiomedical Informatics Training Program, Stanford University, Stanford, CA.ORCID 0000-0002-3814-5307
Allison W KurianDepartment of Medicine, Stanford University School of Medicine, Stanford, CA.
Jennifer L Caswell-JinDepartment of Medicine, Stanford University School of Medicine, Stanford, CA.
George W SledgeDepartment of Medicine, Stanford University School of Medicine, Stanford, CA.
Nigam H ShahDepartment of Biomedical Data Science, Stanford University, Stanford, CA.
Suzanne R TamangDepartment of Biomedical Data Science, Stanford University, Stanford, CA.
Stanford University · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4M
Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
NCATS NIH HHS UL1 TR003142NCCDPHP CDC HHS U58 DP000807NCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNCI NIH HHS P30 CA124435
6 · The paper itself

Abstract

objectivesMost population-based cancer databases lack information on metastatic recurrence. Electronic medical records (EMR) and cancer registries contain complementary information on cancer diagnosis, treatment and outcome, yet are rarely used synergistically. To construct a cohort of metastatic breast cancer (MBC) patients, we applied natural language processing techniques within a semisupervised machine learning framework to linked EMR-California Cancer Registry (CCR) data. MATERIALS AND

methodsWe studied all female patients treated at Stanford Health Care with an incident breast cancer diagnosis from 2000 to 2014. Our database consisted of structured fields and unstructured free-text clinical notes from EMR, linked to CCR, a component of the Surveillance, Epidemiology and End Results Program (SEER). We identified

resultsThere were 11 459 breast cancer patients in total and the median follow-up time was 96.3 months. We identified 1886 MBC patients, 512 (27.1%) of whom were DISCUSSION AND

conclusionTo enable population-based research on MBC, we developed a framework for retrospective case detection combining EMR and CCR data. Our classifier achieved good AUC, sensitivity, and specificity without expert-labeled examples.

Indexed as

cancer distant recurrenceelectronic medical recordsnatural language processingSEERsemi-supervised machine learning

Identifiers

PMID32025650
PMCPMC6994019
OpenAlexW2909620035

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.