Evidence map›Paper›PMID 32025639›Full record

ArticleJAMIA open2019

An integrated web application for decision support and automation of EHR workflow: a case study of current challenges to standards-based messaging and scalability from the EMBED trial.

Edward R Melnick, Wesley C Holland, Osama M Ahmed, Anthony K Ma, Sean S Michael, Howard S Goldberg, Christian Lagier, Gail D'Onofrio, Tomek Stachowiak, Cynthia Brandt and 1 more

Abstract readCase Reports
In one paragraph

Article in JAMIA open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. VIEWER: an extensible visual analytics framework for enhancing mental healthcare.Journal of the American Medical Informatics Association : JAMIA · 2026
    Article
  7. Article
  8. Article
  9. Article
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  11. Article
  12. Article
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  16. The technical landscape for patient-centered CDS: progress, gaps, and challenges.Journal of the American Medical Informatics Association : JAMIA · 2022
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Edward R MelnickDepartment of Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Wesley C HollandYale University School of Medicine, New Haven, Connecticut, USA.
Osama M AhmedYale University School of Medicine, New Haven, Connecticut, USA.
Anthony K MaYale University School of Medicine, New Haven, Connecticut, USA.
Sean S MichaelDepartment of Emergency Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Howard S GoldbergDepartment of Medicine, University of Massachusetts Medical School-Baystate, Springfield, Massachusetts, USA.
Christian LagierTechSpring at Baystate Health, Springfield, Massachusetts, USA.
Gail D'OnofrioDepartment of Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Tomek StachowiakYale New-Haven Health, Information Technology Services, New Haven, Connecticut, USA.
Cynthia BrandtDepartment of Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Yauheni SoladYale University School of Medicine, New Haven, Connecticut, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NIH Health Care Systems Research Collaboratory-Coordinating Center (U24)U24AT009676 · NCCIH · DUKE UNIVERSITY · PI LESLEY H CURTIS, Adrian Hernandez · 2017 to 2026
$21.5M
EMBED: Pragmatic trial of user-centered clinical decision support to implement EMergency department-initiated BuprenorphinE for opioid use DisorderUH3DA047003 · NIDA · YALE UNIVERSITY · PI D'ONOFRIO, GAIL, MELNICK, EDWARD ROBERT · 2019 to 2022
$7.2M
Short-Term Reserch Training: Students in Health SchoolsT35HL007649 · NHLBI · YALE UNIVERSITY · PI Sarwat I Chaudhry, Erica L Herzog · 1987 to 2026
$5.7M
EMBED: Pragmatic trial of user-centered clinical decision support to implement EMergency department-initiated BuprenorphinE for opioid use DisorderUG3DA047003 · NIDA · YALE UNIVERSITY · PI D'ONOFRIO, GAIL, MELNICK, EDWARD ROBERT · 2018 to 2018
$819k
NCATS NIH HHS UL1 TR001863NCCIH NIH HHS U24 AT009676NHLBI NIH HHS T35 HL007649NIDA NIH HHS UG3 DA047003NIDA NIH HHS UH3 DA047003
6 · The paper itself

Abstract

Computerized clinical decision support (CDS) faces challenges to interoperability and scalability. Centralized, web-based solutions offer a mechanism to share the cost of CDS development, maintenance, and implementation across practices. Data standards have emerged to facilitate interoperability and rapid integration of such third-party CDS. This case report describes the challenges to implementation and scalability of an integrated, web-based CDS intervention for EMergency department-initiated BuprenorphinE for opioid use Disorder which will soon be evaluated in a trial across 20 sites in five healthcare systems. Due to limitations of current standards, security concerns, and the need for resource-intensive local customization, barriers persist related to centralized CDS at this scale. These challenges demonstrate the need and importance for future standards to support two-way messaging (read and write) between electronic health records and web applications, thus allowing for more robust sharing across health systems and decreasing redundant, resource-intensive CDS development at individual sites.

Indexed as

buprenorphineclinical decision support systemsEHR interoperabilityemergency department-initiated buprenorphineuser-centered design

Identifiers

PMID32025639
PMCPMC6994013

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.