Evidence map›Paper›PMID 32025629›Full record

ArticleBMC rheumatology2020

Ultrasound detects synovitis in replaced and other surgically operated joints in rheumatoid arthritis patients.

Evan A Choate, Gurjit S Kaeley, Jenny Brook, Roy D Altman, John D FitzGerald, Astrid R Floegel-Shetty, David A Elashoff, Veena K Ranganath

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01717859 phase4completednot on this map

Musculoskeletal Ultrasound in Predicting Early Dose Titration With Tocilizumab

TypeinterventionalSponsorUniversity of California, Los AngelesRan2014 to 2017Enrolled74ConditionsRheumatoid ArthritisArmsTocilizumab
NCT02321930 phase4completednot on this map

Musculoskeletal Ultrasound Assessment of Therapeutic Response of Tofacitinib in Rheumatoid Arthritis Patients

TypeinterventionalSponsorUniversity of California, Los AngelesRan2016 to 2017Enrolled37ConditionsRheumatoid ArthritisArmstofacitinib 5mg po bid
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Evan A Choate1Department of Medicine, Division of Rheumatology, University of California, Los Angeles, CA USA.
Gurjit S Kaeley2College of Medicine, University of Florida, Jacksonville, Florida USA.
Jenny Brook3Department of Medicine/Biostatistics, Division of General Internal Medicine and Health Services Research, University of California, Los Angeles, CA USA.
Roy D Altman1Department of Medicine, Division of Rheumatology, University of California, Los Angeles, CA USA.
John D FitzGerald1Department of Medicine, Division of Rheumatology, University of California, Los Angeles, CA USA.
Astrid R Floegel-Shetty3Department of Medicine/Biostatistics, Division of General Internal Medicine and Health Services Research, University of California, Los Angeles, CA USA.
David A Elashoff3Department of Medicine/Biostatistics, Division of General Internal Medicine and Health Services Research, University of California, Los Angeles, CA USA.
Veena K Ranganath1Department of Medicine, Division of Rheumatology, University of California, Los Angeles, CA USA.ORCID 0000-0003-3417-9478
University of California, Los Angeles · USUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundJoint replacements continue to occur during a rheumatoid arthritis (RA) patient's lifetime despite significant advances in available treatment options. The purpose of this study was to examine and quantify synovitis in surgically operated joints by ultrasound (US) in RA patients starting a new therapeutic agent.

methodsRA subjects were enrolled in either tocilizumab or tofacitinib open-label, investigator-initiated trials and were assessed by ultrasound. In a subset of RA patients with joint replacements and/or operations of joint areas (OJA; e.g. joint arthroscopies, fusions, and synovectomies), joint-level scores of synovitis were compared between replaced joints, OJAs, and native joints. Joint-level synovitis was measured by grayscale (GSUS (0-3)) and power Doppler (PDUS (0-3)) at baseline and follow-up (3-6 months). McNemar's test or Wilcoxon signed rank test utilized the mixed effects ordinal logistic regression models.

resultsTwenty RA patients had a total of 25 replaced joints and 24 OJA. All replaced joints had GSUS> 1 and 92% had PDUS> 1 at baseline, while OJA and native joints had lower evidence of GSUS> 1 (37.5, 38% respectively) and PDUS> 1 (45.8, 62% respectively). GSUS and PDUS semiquantitative scores improved significantly with treatment in replaced joints (

conclusionsIn RA, joint replacement does not eliminate or prevent ultrasound measured synovitis, where all replaced joints have some evidence of US synovitis. US can also act as a potential marker of response to therapy in replaced joints. Scoring US synovitis in replaced joints should be considered in ultrasound RA clinical trials.

trial registrationClinicalTrials.gov NCT01717859 (registered 10/31/2012); ClinicalTrials.gov NCT02321930 (registered 12/22/2014).

Indexed as

Arthritis, rheumatoidJointsResponseSurgical procedures operativeSynovitisUltrasonography

Identifiers

PMID32025629
PMCPMC6996180
OpenAlexW3009482406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.