Evidence map›Paper›PMID 32025586›Full record

ArticleContemporary clinical trials communications2020

Design of an anti-inflammatory diet (ITIS diet) for patients with rheumatoid arthritis.

Marta F Bustamante, Meritxall Agustín-Perez, Francesca Cedola, Roxana Coras, Rekha Narasimhan, Shahrokh Golshan, Monica Guma

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Contemporary clinical trials communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07713940 (Effect of Anti-inflammatory Diet in Systemic Lupus Erythematous), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07713940 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Anti-inflammatory Diet in Systemic Lupus Erythematous

TypeinterventionalSponsorUniversity of California, San DiegoRan2026 to 2029Enrolled36ConditionsSystemic Lupus Erthematosus (SLE)Armsanti-inflammatory diet
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 49 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. [Nutrition and fasting].Zeitschrift fur Rheumatologie · 2024
    Article
  12. Article
  13. Observational
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Global epidemiology of rheumatoid arthritis.Nature reviews. Rheumatology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Marta F BustamanteDepartment of Medicine, University of California San Diego, San Diego, CA, USA.
Meritxall Agustín-PerezDepartment of Medicine, University of California San Diego, San Diego, CA, USA.
Francesca CedolaDepartment of Medicine, University of California San Diego, San Diego, CA, USA.
Roxana CorasDepartment of Medicine, University of California San Diego, San Diego, CA, USA.
Rekha NarasimhanDepartment of Medicine, University of California San Diego, San Diego, CA, USA.
Shahrokh GolshanDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Monica GumaDepartment of Medicine, University of California San Diego, San Diego, CA, USA.
University of California San Diego · USUniversitat Autònoma de Barcelona · ES

Funding

Rheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8M
NIAMS NIH HHS T32 AR064194
6 · The paper itself

Abstract

backgroundRheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability. Although recent pharmaceutical advances have improved treatment of RA, patients with RA often inquire about dietary interventions to improve RA symptoms, as they perceive rapid changes in their symptoms after consumption of certain foods. There is evidence that some ingredients have pro- or anti-inflammatory effects. In addition, recent literature has shown a link between diet and microbiome changes. Both diet and the gut microbiome are linked to circulating metabolites that may modulate inflammation. However, evidence of the effects of an anti-inflammatory and probiotic-rich diet in patients with RA is scarce. There is also a need for biological data to support its anti-inflammatory effects.

methodsThe main goal of this study is to delineate the design process for a diet tailored to our RA population. To achieve this goal, we collected information on diet, supplements, cooking methods, and intake of different ingredients for each patient. Different groups were interviewed, and their feedback was assessed to design a diet that incorporates suggested anti-inflammatory ingredients in a manner that was easy for patients to adopt based on their lifestyles and backgrounds.

resultsWe designed a diet that includes a high intake of potential anti-inflammatory ingredients. Feedback from highly motivated patients was critical in constructing an anti-inflammatory diet (ITIS diet) with elevated adherence.

conclusionIn order to tailor our diet, we surveyed our patients on several different parameters. We obtained important feedback on how feasible our ITIS diet is for RA patients. Using this feedback, we made minor improvements and finalized the design of the ITIS diet. This diet is being used in an on-going pilot study to determine their anti-inflammatory effect in pain and joint swelling in RA patients.

trial registrationNot applicable.

Indexed as

Anti-inflammatory dietDiet designITIS dietMicrobiomeRheumatoid arthritis

Identifiers

PMID32025586
PMCPMC6997513
OpenAlexW3001527612

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.