ArticleToxicology reports2020
Testicular protective and antioxidant effects of selenium nanoparticles on Monosodium glutamate-induced testicular structure alterations in male mice.
Article in Toxicology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 77 citations in OpenAlex.
- Ganoderic acid D as a potential modulator of steroidogenic enzymes: Protective effects of Cucurbita maxima Duch. seed extract against nonylphenol-induced reproductive toxicity.Journal of computer-aided molecular design · 2026Article
- Germ cell risk assessment of combined exposure to monosodium glutamate and bisphenol A in male SD rat: deciphering the molecular mechanisms.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Selenium mitigates cyclophosphamide-induced toxicity on sperm quality in mice: An experimental study.International journal of reproductive biomedicine · 2026Article
- Attenuation of carbon tetrachloride-induced male reproductive damage in albino laboratory rats using varying concentrations of supplemented soybean.Open veterinary journal · 2026Article
- Protective Effects of Eugenol Against Monosodium Glutamate-Induced Reproductive Toxicity in Male Wistar Rats.Journal of xenobiotics · 2026Article
- Article
- Protective effects of selenium nanoparticles against X-ray-induced testicular damage in rats: An integrated experimental and Monte Carlo simulation study.International journal of reproductive biomedicine · 2025Article
- Monosodium glutamate exacerbated the lipopolysaccharide-induced reproductive toxicity of male Wistar rats.BMC pharmacology & toxicology · 2025Article
- Fucoxanthin-Loaded Solid Lipid Nanoparticles Exert Potent Therapeutic Efficacy in Combating High-Fat Diet Induced Obesity in Mice.International journal of molecular sciences · 2025Article
- The protective efficacy of omega-3 polyunsaturated fatty acids on oxidative stress, inflammation, neurotransmitter perturbations, and apoptosis induced by monosodium glutamate in the brain of male rats.Metabolic brain disease · 2025Article
- A comprehensive review on potential role of selenium, selenoproteins and selenium nanoparticles in male fertility.Heliyon · 2024Review
- Mitochondrial Differentiation during Spermatogenesis: Lessons fromInternational journal of molecular sciences · 2024Review
- Disruptive consequences of monosodium glutamate on male reproductive function: A review.Current research in toxicology · 2024Review
- Novel insights into the synergistic effects of selenium nanoparticles and metformin treatment of letrozole - induced polycystic ovarian syndrome: targeting PI3K/Akt signalling pathway, redox status and mitochondrial dysfunction in ovarian tissue.Redox report : communications in free radical research · 2023Article
- Article
- Apocynin Ameliorates Monosodium Glutamate Induced Testis Damage by Impaired Blood-Testis Barrier and Oxidative Stress Parameters.Life (Basel, Switzerland) · 2023Article
- Beneficial Effect of Selenium Doped Carbon Quantum Dots Supplementation on the in vitro Development Competence of Ovine Oocytes.International journal of nanomedicine · 2022Article
- Research progress of nano selenium in the treatment of oxidative stress injury during hepatic ischemia-reperfusion injury.Frontiers in pharmacology · 2022Review
- RETRACTED: Efficacy of Vanadyl Sulfate and Selenium Tetrachloride as Anti-Diabetic Agents against Hyperglycemia and Oxidative Stress Induced by Diabetes Mellitus in Male Rats.Current issues in molecular biology · 2021Article
- In Situ Neutral System Synthesis, Spectroscopic, and Biological Interpretations of Magnesium(II), Calcium(II), Chromium(III), Zinc(II), Copper(II) and Selenium(IV) Sitagliptin Complexes.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSelenium has a protective antioxidant effect on several tissues. Monosodium glutamate (MSG), MSG has been known as flavor enhancer that influences reversely on male reproductive systems and having a number of side effects, including reproductive toxicity.
objectivesThe current study aims to evaluate the possible ameliorative functions of selenium nanoparticles (SeNPs) on MSG-induced reproductive toxicity. MATERIALS AND
methodsIn total, 42 male mice included in this study were divided into six groups: control, MSG (LD), MSG (HD), SeNPs, MSG (LD) plus SeNPs and finally MSG (HD) plus SeNPs. Testosterone hormone, tumor necrosis factor-alpha (TNF-α), as well as the antioxidant biomarkers: superoxide dismutase [SOD], glutathione peroxidase [GPx], catalase [CAT] and marker of lipid peroxidation [MDA], were examined. Histological and comet assay variations in the testicular tissues as markers of testicular damage after the MSG administration in two doses (MSG-LD and MSG-HD) either alone or combined with SeNPs.MSG in two doses (LD and HD) genotoxic effects were also evaluated and the ameliorative role of SeNPs on the testicular tissues were recorded.
resultsResults proved that the administration of SeNPs diminished the effect of MSG (LD and HD)-that induced decrease in testosterone hormone levels and elevated oxidative stress markers markedly. SeNPs had a potent antioxidant effect and elevated the antioxidant enzymes significantly and decreased lipid peroxidation markers as compared with MSG either (LD and HD) groups.
conclusionIt is clear from the data that SeNPs inhibit testicular injury and improve the antioxidant state in male mice.
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