ArticleNature2020
Live-animal imaging of native haematopoietic stem and progenitor cells.
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Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers.
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150citing papers in PubMed
22.4field-weighted citation impact, top 1% of its field
What it found
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Who cites it
150 citing papers in PubMed, 242 citations in OpenAlex.
- Mechanisms of Hematopoietic Stem Cell Aging and Emerging Rejuvenation Strategies.Stem cell reviews and reports · 2026Review
- Natural killer cells against viral infection: from basic biology to immunotherapy.Precision clinical medicine · 2026Review
- A progeria syndrome links DNA hypermethylation to age-related pathology.Nature genetics · 2026Article
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- A Novel 3D Visualization Method in Mice Identifies the Periportal Lamellar Complex (PLC) as a Key Regulator of Hepatic Ductal and Neuronal Branching Morphogenesis.bioRxiv : the preprint server for biology · 2026Article
- The bone marrow microenvironment during homeostasis and after myeloablation.Journal of bone and mineral metabolism · 2026Review
- Understanding hairy cell leukemia in the context of mature B-cell neoplasms: tumor microenvironment and extracellular vesicle contribution to disease pathogenesis.Frontiers in immunology · 2026Review
- The oncogenic role of ecotropic viral integration site 1 in hematological malignancies: mechanisms of activation and leukemogenesis.Frontiers in immunology · 2026Review
- Thrombopoietin increases susceptibility for EVI1 + KMT2A-MLLT3-driven AML expressing stem cell genes linked to poor outcome.Nature communications · 2025Article
- Gene therapy for hemoglobinopathies: Clinical trial results and biology of hematopoietic stem cell and the bone marrow niche.Cell reports. Medicine · 2025Review
- A single-cell hematopoietic microenvironmental atlas reveals progressive maturation of bone marrow vascular niche.Cell regeneration (London, England) · 2025Article
- Reconstruction of hematopoietic stem cell nichesMaterials today. Bio · 2025Review
- How Faithful Flt3-Cre Mouse is to Hematopoietic Lineage Tracing?Stem cell reviews and reports · 2025Review
- Noninvasive Optoacoustic Imaging of Oxygen Saturation Reveals Hypoxic Hematopoietic Bone Marrow during Systemic Inflammation.Nano letters · 2025Article
- Participation of the Periosteum, Endosteum, and Hematogenous Marrow in the Early Osseointegration of a Titanium Implant Inserted in Contact with the Hematogenous Marrow.Medicina (Kaunas, Lithuania) · 2025Article
- DNMT3A regulates murine megakaryocyte-biased hematopoietic stem cell fate decisions.Blood advances · 2025Article
- Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells.Nature aging · 2025Article
- Future direction: molecular imaging-based stem cell research.European journal of nuclear medicine and molecular imaging · 2025Article
- How oxygenation shapes immune responses: emerging roles for physioxia and pathological hypoxia.Nature reviews. Immunology · 2025Review
90 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 12 institutions in 3 countries.
Constantina Christodoulou *Stem Cell Program, Boston Children's Hospital, Boston, MA, USA.
Joel A Spencer *Advanced Microscopy Program, Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
Shu-Chi A Yeh *Advanced Microscopy Program, Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
Raphaël TurcotteAdvanced Microscopy Program, Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
Konstantinos D KokkaliarisDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Riccardo PaneroDepartment of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Azucena RamosStem Cell Program, Boston Children's Hospital, Boston, MA, USA.
Guoji GuoDana Farber/Boston Children's Cancer and Blood Disorders Center, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Negar SeyedhassantehraniDepartment of Bioengineering, University of California Merced, Merced, CA, USA.
Tatiana V EsipovaDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
Sergei A VinogradovDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
Sarah RudzinskasDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Yi ZhangDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Archibald S PerkinsDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Stuart H OrkinDana Farber/Boston Children's Cancer and Blood Disorders Center, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Raffaele A CalogeroDepartment of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Timm SchroederDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Charles P LinAdvanced Microscopy Program, Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA. charles_lin@hms.harvard.edu.
Fernando D CamargoStem Cell Program, Boston Children's Hospital, Boston, MA, USA. fernando.camargo@childrens.harvard.edu.
University of Rochester Medical Center · USCenter for Systems Biology · USETH Zurich · CHMassachusetts General Hospital · USUniversity of Pennsylvania · USUniversity of Turin · ITBoston Children's Hospital · USDana-Farber/Boston Children's Cancer and Blood Disorders Center · USHarvard University · USHoward Hughes Medical Institute · USNovartis (United States) · USUniversity of California, Merced · US
Funding
Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DANIEL G TENEN · 2017 to 2026
$24.6MProject-002U54DK110805 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI ORKIN, STUART H, ZON, LEONARD IRA · 2016 to 2020
$5.9MMolecular regulation of native hematopoiesisR01HL128850 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CAMARGO, FERNANDO · 2016 to 2024
$4.9MCell and Molecular Dynamics of Hematopoiesis In VivoR24DK103074 · NIDDK · HARVARD UNIVERSITY · PI SCADDEN, DAVID T · 2015 to 2018
$3.0MSingle cell approach to uncovering factors regulating HSC division symmetry in vivoR01DK115577 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ITO, KEISUKE, LIN, CHARLES P. · 2017 to 2021
$2.9MMulti-wavelength femtosecond laser sources for intravital multiphoton microscopyR01EB017274 · NIBIB · CORNELL UNIVERSITY · PI LIN, CHARLES P., XU, CHRIS · 2013 to 2016
$2.6M(PQC2) Localization as a determinant of cancer dormancyR01CA194596 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LIN, CHARLES P., SCADDEN, DAVID T · 2015 to 2018
$2.2MFunction of the PR domain of the MDSI-EVI1 in MLL fusion protein leukemogenesisR01CA175761 · NCI · UNIVERSITY OF ROCHESTER · PI PERKINS, ARCHIBALD S. · 2014 to 2018
$1.6MDendritic upconverting nanoparticles for multiphoton imaging and sensingR01EB018464 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI VINOGRADOV, SERGEI · 2014 to 2017
$1.5MEnabling widespread use of high resolution imaging of oxygen in the brainR24NS092986 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BOAS, DAVID A, VINOGRADOV, SERGEI · 2015 to 2018
$1.2MImage guided profiling of the native HSC nicheR01DK123216 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CAMARGO, FERNANDO, LIN, CHARLES P. · 2019 to 2021
$941kNCI NIH HHS R01 CA175761NCI NIH HHS R01 CA194596NHLBI NIH HHS P01 HL131477NHLBI NIH HHS R01 HL128850NIBIB NIH HHS R01 EB017274NIBIB NIH HHS R01 EB018464NIDDK NIH HHS R01 DK115577NIDDK NIH HHS R01 DK123216NIDDK NIH HHS R24 DK103074NIDDK NIH HHS U54 DK110805NINDS NIH HHS R24 NS092986
Abstract
The biology of haematopoietic stem cells (HSCs) has predominantly been studied under transplantation conditions
Indexed as
Molecular ImagingAnimalsBone RemodelingCell MovementCell ProliferationCell SurvivalFemalefms-Like Tyrosine Kinase 3Genes, ReporterHematopoietic Stem CellsHypoxiaMaleMDS1 and EVI1 Complex Locus ProteinMiceOxygenSkullFlt3 protein, mousefms-Like Tyrosine Kinase 3MDS1 and EVI1 Complex Locus ProteinMecom protein, mouseOxygen
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.