ArticleNature2020
AQP5 enriches for stem cells and cancer origins in the distal stomach.
Abstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 176 citations in OpenAlex.
- Review
- Targeting the YAP-BST2 Axis Overcomes Intrinsic Anti-PD-1 Resistance in Metastatic Gastric Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The expression of stemness markers in organoids according to histological subtypes of gastric cancer.Korean journal of clinical oncology · 2026Article
- Stromal BMP signalling maintains stem cell genome integrity and prevents gastric cancer initiation.Cell death & disease · 2026Article
- Gastric intestinal metaplasia: unraveling the multifactorial pathogenesis and advancing risk stratification for gastric cancer prevention.Cellular and molecular life sciences : CMLS · 2026Review
- Single-nucleus multiome sequencing identifies candidate regulators of mouse gastric epithelial homeostasis.bioRxiv : the preprint server for biology · 2026Article
- Ligand-dependent Wnt signaling promotes gastric cancer metastasis through hyaluronan expression in microenvironment.Nature communications · 2026Article
- Regulation and Function of Sox2 and CD44 Expression in the Stomach by Bone Morphogenetic Protein Signaling.Gastro hep advances · 2026Article
- Article
- NOX1 and NPY1R mark regional colon stem cell populations that serve as cancer origins in vivo.Nature cell biology · 2025Article
- Targeting AQP5-mediated arginine deprivation in gastric cancer stem cells restores NK cell anti-tumor immunity.Cell reports. Medicine · 2025Article
- Comprehensive metabolomic and epigenomic characterization of microsatellite stable BRAF-mutated colorectal cancer.Oncogene · 2025Article
- PI3 expression predicts recurrence after chemotherapy with DNA-damaging drugs in gastric cancer.The Journal of pathology · 2025Article
- Sleeve gastrectomy reveals the plasticity of the human gastric epithelium.Nature communications · 2025Article
- Standard: Human gastric organoids.Cell regeneration (London, England) · 2025Article
- The plasticity of epithelial cells and its potential in the induced differentiation of gastric cancer.Cell death discovery · 2024Review
- Article
- CCKBR+ cancer cells contribute to the intratumor heterogeneity of gastric cancer and confer sensitivity to FOXO inhibition.Cell death and differentiation · 2024Article
- Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within interleukin-6 family cytokines.Cell reports · 2024Article
- Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
24 authors at 12 institutions in 4 countries.
Si Hui Tan *A*STAR Institute of Medical Biology, Singapore, Singapore.
Yada Swathi *A*STAR Institute of Medical Biology, Singapore, Singapore.
Shawna TanA*STAR Institute of Medical Biology, Singapore, Singapore.
Jasmine GohA*STAR Institute of Medical Biology, Singapore, Singapore.
Ryo SeishimaA*STAR Institute of Medical Biology, Singapore, Singapore.
Kazuhiro MurakamiDivision of Epithelial Stem Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Masanobu OshimaDivision of Genetics, Cancer Research Institute, Nano-Life Science Institute, Kanazawa University, Kanazawa, Japan.
Toshikatsu TsujiDepartment of Gastroenterological Surgery, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
Phyllis PhuahA*STAR Institute of Medical Biology, Singapore, Singapore.
Liang Thing TanA*STAR Institute of Medical Biology, Singapore, Singapore.
Esther WongA*STAR Institute of Medical Biology, Singapore, Singapore.
Aliya FatehullahA*STAR Institute of Medical Biology, Singapore, Singapore.
Taotao ShengCancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore, Singapore.
Shamaine Wei Ting HoCancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore, Singapore.
Heike I GrabschDepartment of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center+, Maastricht, The Netherlands.
Supriya SrivastavaDepartment of Pathology, National University Health System, Singapore, Singapore.
Ming TehDepartment of Pathology, National University Health System, Singapore, Singapore.
Simon L I J DenilSkin Research Institute of Singapore, Singapore, Singapore.
Seri MustafahA*STAR Singapore Immunology Network, Singapore, Singapore.
Patrick TanCancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore, Singapore.
Asim ShabbirDepartment of Surgery, National University Health System, Singapore, Singapore.
Jimmy SoDepartment of Surgery, National University Health System, Singapore, Singapore.
Khay Guan YeohDepartment of Medicine, National University of Singapore, Singapore, Singapore.
Nick BarkerA*STAR Institute of Medical Biology, Singapore, Singapore. Nicholas.barker@imb.a-star.edu.sg.
Agency for Science, Technology and Research · SGNational University Health System · SGInstitute of Medical Biology · SGKanazawa University · JPNational University of Singapore · SGDuke-NUS Medical School · SGIshikawa Prefectural Central Hospital · JPNanyang Technological University · SGNational Skin Centre · SGNational University Cancer Institute, Singapore · SGSingapore Immunology Network · SGUniversity of Leeds · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
LGR5 marks resident adult epithelial stem cells at the gland base in the mouse pyloric stomach
Indexed as
AnimalsAquaporin 5BiomarkersCarcinogenesisHumansMiceNeoplastic Stem CellsPylorusReceptors, G-Protein-CoupledStomachStomach NeoplasmsWnt Signaling PathwayAQP5 protein, humanAqp5 protein, mouseAquaporin 5BiomarkersLgr5 protein, mouseReceptors, G-Protein-Coupled
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.