Evidence map›Paper›PMID 32025031›Full record

ArticleNature2020

Neuronal programming by microbiota regulates intestinal physiology.

Yuuki Obata, Álvaro Castaño, Stefan Boeing, Ana Carina Bon-Frauches, Candice Fung, Todd Fallesen, Mercedes Gomez de Agüero, Bahtiyar Yilmaz, Rita Lopes, Almaz Huseynova and 8 more

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In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 222 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
222citing papers in PubMed, 1 pooled it
23.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

222 citing papers in PubMed, 1 synthesis or guideline pooled it, 332 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
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  5. Article
  6. Review
  7. Phenotypic switching of gastrointestinal smooth muscle cells and the regulatory role of macrophages: a literature review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Intestinal muscularis in health and disease.Communications biology · 2026
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

162 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 4 countries.

Yuuki ObataThe Francis Crick Institute, London, UK. Yuuki.Obata@crick.ac.uk.
Álvaro CastañoThe Francis Crick Institute, London, UK.
Stefan BoeingThe Francis Crick Institute, London, UK.
Ana Carina Bon-FrauchesThe Francis Crick Institute, London, UK.
Candice FungLaboratory of Enteric Neuroscience (LENS), Translational Research in Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, University of Leuven, Leuven, Belgium.
Todd FallesenThe Francis Crick Institute, London, UK.
Mercedes Gomez de AgüeroMaurice Muller Laboratories (DKF), Universitätsklinik fur Viszerale Chirurgie und Medizin Inselspital, University of Bern, Bern, Switzerland.
Bahtiyar YilmazMaurice Muller Laboratories (DKF), Universitätsklinik fur Viszerale Chirurgie und Medizin Inselspital, University of Bern, Bern, Switzerland.
Rita LopesThe Francis Crick Institute, London, UK.
Almaz HuseynovaThe Francis Crick Institute, London, UK.
Stuart HorswellThe Francis Crick Institute, London, UK.
Muralidhara Rao MaradanaThe Francis Crick Institute, London, UK.
Werend BoesmansBiomedical Research Institute (BIOMED), Hasselt University, Hasselt, Belgium.
Pieter Vanden BergheLaboratory of Enteric Neuroscience (LENS), Translational Research in Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, University of Leuven, Leuven, Belgium.
Andrew J MurraySainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK.
Brigitta Stockinger *The Francis Crick Institute, London, UK.
Andrew J Macpherson *Maurice Muller Laboratories (DKF), Universitätsklinik fur Viszerale Chirurgie und Medizin Inselspital, University of Bern, Bern, Switzerland.
Vassilis Pachnis *The Francis Crick Institute, London, UK. Vassilis.Pachnis@crick.ac.uk.
The Francis Crick Institute · GBKU Leuven · BEUniversity of Bern · CHHasselt University · BEUniversity College London · GBUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural control of the function of visceral organs is essential for homeostasis and health. Intestinal peristalsis is critical for digestive physiology and host defence, and is often dysregulated in gastrointestinal disorders

Indexed as

PeristalsisAnimalsBasic Helix-Loop-Helix ProteinsCytochrome P-450 CYP1A1FemaleGastrointestinal MicrobiomeGerm-Free LifeIntestinesLigandsMaleMiceNeural PathwaysNeuronsReceptors, Aryl HydrocarbonSignal TransductionTranscriptomeAhr protein, mouseBasic Helix-Loop-Helix ProteinsCytochrome P-450 CYP1A1LigandsReceptors, Aryl Hydrocarbon

Identifiers

PMID32025031
OpenAlexW3004904380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.